Lung tumor
Adenocarcinoma
Hepatoid adenocarcinoma



Topic Completed: 1 September 2012

Revised: 31 January 2019, last major update September 2012

Copyright: (c) 2003-2018, PathologyOutlines.com, Inc.

PubMed Search: hepatoid adenocarcinoma lung

Deepali Jain, M.D.
Page views in 2018: 2,006
Page views in 2019 to date: 1,589
Cite this page: Jain D. Hepatoid adenocarcinoma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/lungtumorhepatoid.html. Accessed August 25th, 2019.
Definition / general
  • Resembles hepatocellular carcinoma (HCC)
  • More common in gastric than pulmonary adenocarcinoma
  • Usually older men (range, 35-82 years)
  • High serum AFP
  • Aggressive behavior, often with liver metastases
Case reports
Gross images

Images hosted on other servers:

5 cm tumor with firm white and necrotic parts

Microscopic (histologic) description
  • Liver metastases resemble HCC
Microscopic (histologic) images

Images hosted on other servers:

Papillary or trabecular pattern of HCC-like cells
(A/B), with hyaline globules (C) and AFP+ cells (D)

Immunohistochemistry
Molecular / cytogenetics description
  • 4q-, 8p-, Xq+ (seen in HCC and hepatoblastoma)
Differential diagnosis
  • Metastatic hepatocellular carcinoma, metastatic hepatoid adenocarcinoma from stomach, gallbladder or other site
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