Lung tumor
Hepatoid adenocarcinoma

Author: Deepali Jain, M.D. (see Authors page)

Revised: 5 September 2018, last major update September 2012

Copyright: (c) 2003-2018,, Inc.

PubMed Search: hepatoid adenocarcinoma lung
Cite this page: Jain, D. Hepatoid adenocarcinoma. website. Accessed October 15th, 2018.
Definition / general
  • Resembles hepatocellular carcinoma (HCC)
  • More common in gastric than pulmonary adenocarcinoma
  • Usually older men (range, 35-82 years)
  • High serum AFP
  • Aggressive behavior, often with liver metastases
Case reports
Gross images

Images hosted on other servers:

5 cm tumor with firm white and necrotic parts

Microscopic (histologic) description
  • Liver metastases resemble HCC
Microscopic (histologic) images

Images hosted on other servers:

Papillary or trabecular pattern of HCC-like cells
(A/B), with hyaline globules (C) and AFP+ cells (D)

Molecular / cytogenetics description
  • 4q-, 8p-, Xq+ (seen in HCC and hepatoblastoma)
Differential diagnosis
  • Metastatic hepatocellular carcinoma, metastatic hepatoid adenocarcinoma from stomach, gallbladder or other site