Lung tumor
Adenocarcinoma
Hepatoid adenocarcinoma

Author: Deepali Jain, M.D. (see Authors page)

Revised: 20 December 2016, last major update September 2012

Copyright: (c) 2003-2016, PathologyOutlines.com, Inc.

PubMed Search: hepatoid adenocarcinoma lung
Cite this page: Hepatoid adenocarcinoma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/lungtumorhepatoid.html. Accessed February 20th, 2017.
Definition / General
  • Resembles hepatocellular carcinoma (HCC)
  • More common in gastric than pulmonary adenocarcinoma
  • Usually older men (range, 35-82 years)
  • High serum AFP
  • Aggressive behavior, often with liver metastases
Case Reports
Gross Images

Images hosted on other servers:

5 cm tumor with firm-white and necrotic parts

Micro Description
  • Liver metastases resemble HCC
Micro Images

Images hosted on other servers:

Papillary or trabecular pattern of HCC-like cells
(A/B), with hyaline globules (C) and AFP+ cells (D)

Immunohistochemistry
Molecular / Cytogenetics Description
  • 4q-, 8p-, Xq+ (seen in HCC and hepatoblastoma)
Differential Diagnosis
  • Metastatic hepatocellular carcinoma, metastatic hepatoid adenocarcinoma from stomach, gallbladder or other site