Home   Chapter Home   Jobs   Conferences   Fellowships   Books

Advertisement

Lung tumor

Adenocarcinoma

Hepatoid adenocarcinoma

Reviewer: Deepali Jain, M.D. (see Reviewers page)
Revised:11 January 2013, last major update September 2012
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.

General
=========================================================================

● Resembles hepatocellular carcinoma (HCC)
● More common in gastric than pulmonary adenocarcinoma
● Usually older men (range, 35-82 years)
● High serum AFP
● Aggressive behavior, often with liver metastases

Case reports
=========================================================================

● 36 year old man with AFP producing tumor (Am J Surg Pathol 1997;21:1113)
● 55 year old man with smoking history (Lung Cancer 2002;38:211)

Gross images
=========================================================================

5 cm tumor with firm-white and necrotic parts

Micro description
=========================================================================

● Liver metastases resemble HCC

Micro images
=========================================================================

Papillary or trabecular pattern of HCC-like cells (A/B), with hyaline globules (C) and AFP+ cells (D)

 
Various images

Immunohistochemistry
=========================================================================

● Same as HCC: AFP+, CK8/CK18+, canalicular staining with polyclonal CEA (Am J Surg Pathol 2003;27:1302)
● Different from HCC: CK19+, CK20+ (HCC is rarely CK20+ Eur J Histochem 2009;53:e32) , negative for HepPar1, negative for CK7

Molecular description
=========================================================================

● 4q-, 8p-, Xq+ (seen in HCC and hepatoblastoma)

Differential diagnosis
=========================================================================

● Metastatic hepatocellular carcinoma, metastatic hepatoid adenocarcinoma from stomach, gallbladder or other site

End of Lung tumor > Adenocarcinoma > Hepatoid adenocarcinomal

This information is intended for physicians and related personnel, who understand that medical information is often imperfect, and must be interpreted in the context of a patient's clinical data using reasonable medical judgment. This website should not be used as a substitute for the advice of a licensed physician.

All information on this website is protected by copyright of PathologyOutlines.com, Inc. Information from third parties may also be protected by copyright. Please contact us at copyrightPathOut@gmail.com with any questions (click here for other contact information).