Lung tumor
Benign tumors

Author: Roseann Wu, M.D. (see Auhtors page)

Revised: 22 October 2015, last major update October 2015

Copyright: (c) 2003-2015,, Inc.

PubMed Search: Leiomyoma [title] lung
Definition / General
  • Primary leiomyoma of lung
  • Predominantly female, most commonly in 30s - 40s
  • ~2% of benign lung tumors
  • Solitary, benign
  • Arises from smooth muscle of bronchial tree or pulmonary vasculature
Clinical Features
  • Typically incidental and asymptomatic
  • May present with chest pain, cough, fever, hemoptysis, shortness of breath, pneumonia due to obstruction
  • Biopsy or resection
Radiology description
  • Round or oval, well defined borders
  • Endobronchial lesions may show pneumonia or atelectasis due to obstruction
Prognostic Factors
  • Prognosis and survival excellent
Case Reports
  • Resection is curative
Clinical Images
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White, smooth ovoid lesion

Gross Description
  • Endobronchial lesion may be attached by a broad stalk
  • Firm, white, well circumscribed nodule
Gross Images
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Bronchoscopic resection

Micro Description
  • Bland proliferation of intersecting and whorled smooth muscle fascicles
  • Fusiform spindle cells with no atypia, no hypercellularity, no necrosis, no mitoses
  • May show fibrosis and hyalinization
Micro Images

Bronchial leiomyomas:

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Respiratory epithelium

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Desmin+, myogenin-

Vascular leiomyoma:

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Tumor (center)

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Mature smooth muscle

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Small pulmonary arteries

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Van Gieson elastin

Positive Stains
Negative Stains
Differential Diagnosis
Additional References