Lung tumor
Other carcinoma
Metastatic tumors to lung

Author: Deepali Jain, M.D. (see Authors page)

Revised: 27 December 2016, last major update September 2012

Copyright: (c) 2003-2016, PathologyOutlines.com, Inc.

PubMed Search: metastatic tumors to lung
Cite this page: Metastastic tumors to lung. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/lungtumormetastases.html. Accessed April 23rd, 2017.
Definition / General
  • Lung is a common site of metastases - usually multiple, bilateral, sharply outlined, rapidly growing, more pleomorphic and necrotic than lung primaries, negative for TTF1
  • May appear as multiple discrete nodules in periphery of lung, or as lymphangitis carcinomatosa (peribronchial and perivascular patterns via lymphatics)
  • Rarely appear as intralymphatic microscopic foci that cause pulmonary hypertension
  • Note: metastases can also be from other lung primaries (Am J Surg Pathol 2009;33:1752)
Patterns associated with specific primaries
  • Central cavitation: colonic adenocarcinoma, leiomyosarcoma, squamous cell carcinoma of upper aerodigestive tract
  • Intrabronchial masses: breast, colon, kidney
  • Lepidic pattern: colon, pancreas
  • Lymphangitis carcinomatosis: breast, choriocarcinoma, pancreas, prostate, stomach
  • Nodular metastases: breast, GI, kidney, melanoma., sarcoma
  • Tumor emboli: breast, choriocarcinoma, liver, stomach
Case Reports
Treatment
  • Excision of isolated nodules
Gross Images

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Osteosarcoma

Multiple tumor nodules

Micro Images

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Jaw: Ameloblastoma

Jaw: Ameloblastoma - left: CK AE1; right: p63



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Bladder, urothelial carcinoma

Breast, invasive ductal carcinoma

Chondrosarcoma, dedifferentiated


Colon: adenocarcinoma

Kidney: renal cell carcinoma

Liver: hepatocellular carcinoma

Oropharyngeal carcinoma


Pancreas: adenocarcinoma

Prostate: adenocarcinoma

Testis: choriocarcinoma

Virtual Slides

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Metastatic adenocarcinoma

Metastatic small cell carcinoma

Positive Stains