Lung tumor - Micronodular pneumocyte hyperplasia

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Lung tumor

Benign tumors

Micronodular pneumocyte hyperplasia

Reviewer: Deepali Jain, M.D. (see Reviewers page)
Revised: 8 January 2013, last major update September 2012
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.

General
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● Associated with tubular sclerosis
● Due to loss of heterozygosity on TSC gene (Mod Pathol 2010;23:1251), may coexist with lymphangioleiomyomatosis
● Usually women with shortness of breath
● Considered a hamartoma
● Not progressive

Case reports
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● 16 year old girl with respiratory failure (Histopathology 2002;41:263)
● 51 year old woman with tuberous sclerosis complex but no classical clinical findings (J Med Case Rep 2012 Oct 16;6:352)

Micro description
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● Bland, papillary or tubular, multifocal proliferation of alveolar type II pneumocytes lining thickened alveolar septa; lymphocyte infiltration, clear cell micronodules, no nuclear atypia (Int J Surg Pathol 2010;18:522)

Micro images
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Various images

Positive stains
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● Cytokeratin, surfactant proteins A and B

Negative stains
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● HMB45, ER, PR, SMA, P53, CEA

Differential diagnosis
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● Lymphangioleiomyomatosis

End of Lung tumor > Benign tumors > Micronodular pneumocyte hyperplasia

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