Reviewer: Deepali Jain, M.D. (see Reviewers page)
Revised: 12 January 2013, last major update September 2012
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.
● Associated with nodal metastases of similar histology, intrapulmonary metastases, non-smokers
● Poorer survival than non-papillary for stage I (79% vs. 93%, Am J Surg Pathol 2003;27:101, Am J Surg Pathol 2002;26:358)
● 68 year old woman with incidental brain metastases with micropapillary structures (Arch Pathol Lab Med 2003;127:e313)
● Small papillary tufts without a fibrovascular core
● Associated with other histologic subtypes, small cluster invasion / stromal invasion which is defined as acinar-papillary tumor structures with single or small clusters of carcinoma cells invading stroma within fibrotic foci
● May have "aerogenous" micropapillary component of tumor cells floating within alveolar spaces (Diagn Pathol 2012 Jan 6;7:3)
Papillary and micropapillary structures
● CK7 (93%), TTF1 (80%), CK20 (13%)
● Kras, EGFR, BRAF mutations (Am J Clin Pathol 2009;131:694)
● Hum Pathol 2008;39:324, Mod Pathol 2007;20:638, Mod Pathol 2007;20:514
● Mod Pathol 2011;24:653, Histopathology 2005;46:677, Histopathology 2011;59:1204)
End of Lung tumor > Adenocarcinoma > Micropapillary
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