Lung tumor

Topic Completed: 1 October 2014

Revised: 31 January 2019, last major update October 2015

Copyright: (c) 2003-2015,, Inc.

PubMed Search: Micropapillary [title] lung

Negar Rassaei, M.D.
Page views in 2018: 1,900
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Cite this page: Rassaei N. Micropapillary adenocarcinoma. website. Accessed September 19th, 2019.
Definition / general
Prognostic factors
  • Often presents at late stage
  • Considered a poor prognostic variant due to more aggressive clinical course
  • Associated with higher rate of pleural invasion, nodal, intra- and extra-pulmonary metastasis
Case reports
Gross images
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Gray white tumor

Microscopic (histologic) description
  • Either papillary tufts without fibrovascular core connected to alveolar walls or a detached shedding tumor within alveolar spaces
  • Also ring-like glandular structures within alveolar spaces and psammoma bodies
Microscopic (histologic) images
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Micropapillary component

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Stromal micropapillary pattern

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Papillary and micropapillary structures

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Resected lymph node

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E cadherin, CD44

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MUC1, D240, CD34

Positive stains
  • Has typical lung adenocarcinoma immunoprofile of CK7 (+), CK20 (-), TTF1 (+), and NapsinA (+)
Molecular / cytogenetics description
Additional references
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