Lung tumor - Micropapillary adenocarcinoma

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Lung tumor

Adenocarcinoma

Micropapillary

Reviewer: Deepali Jain, M.D. (see Reviewers page)
Revised: 12 January 2013, last major update September 2012
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.

General
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● Associated with nodal metastases of similar histology, intrapulmonary metastases, non-smokers
● Poorer survival than non-papillary for stage I (79% vs. 93%, Am J Surg Pathol 2003;27:101, Am J Surg Pathol 2002;26:358)

Case reports
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● 68 year old woman with incidental brain metastases with micropapillary structures (Arch Pathol Lab Med 2003;127:e313)

Gross images
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Various images

Micro description
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● Small papillary tufts without a fibrovascular core
● Associated with other histologic subtypes, small cluster invasion / stromal invasion which is defined as acinar-papillary tumor structures with single or small clusters of carcinoma cells invading stroma within fibrotic foci
● May have "aerogenous" micropapillary component of tumor cells floating within alveolar spaces (Diagn Pathol 2012 Jan 6;7:3)

Micro images
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Various images

Papillary and micropapillary structures

Positive stains
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● CK7 (93%), TTF1 (80%), CK20 (13%)

Molecular description
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● Kras, EGFR, BRAF mutations (Am J Clin Pathol 2009;131:694)

Additional references
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● Hum Pathol 2008;39:324, Mod Pathol 2007;20:638, Mod Pathol 2007;20:514
● Mod Pathol 2011;24:653, Histopathology 2005;46:677, Histopathology 2011;59:1204)

End of Lung tumor > Adenocarcinoma > Micropapillary

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