Lung
Adenocarcinoma
Micropapillary


Topic Completed: 1 October 2014

Minor changes: 1 September 2020

Copyright: 2003-2020, PathologyOutlines.com, Inc.

PubMed Search: Micropapillary [title] lung

Negar Rassaei, M.D.
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Cite this page: Rassaei N. Micropapillary. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/lungtumormicropapillary.html. Accessed September 30th, 2020.
Definition / general
Prognostic factors
  • Often presents at late stage
  • Considered a poor prognostic variant due to more aggressive clinical course
  • Associated with higher rate of pleural invasion, nodal, intra- and extra-pulmonary metastasis
Case reports
Gross images

Images hosted on other servers:
Gray white tumor

Gray white tumor

Microscopic (histologic) description
  • Either papillary tufts without fibrovascular core connected to alveolar walls or a detached shedding tumor within alveolar spaces
  • Also ring-like glandular structures within alveolar spaces and psammoma bodies
Microscopic (histologic) images

Images hosted on other servers:
Micropapillary component

Micropapillary component

Stromal micropapillary pattern

Stromal micropapillary pattern

Resected lymph node

Resected lymph node

E cadherin, CD44

E cadherin, CD44

MUC1, D240, CD34

MUC1, D240, CD34

Positive stains
  • Has typical lung adenocarcinoma immunoprofile of CK7 (+), CK20 (-), TTF1 (+), and Napsin A (+)
Molecular / cytogenetics description
Additional references
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