Lung tumor

Author: Negar Rassaei, M.D. (see Authors page)

Revised: 18 October 2015, last major update October 2015

Copyright: (c) 2003-2015,, Inc.

PubMed Search: Micropapillary [title] lung

Definition / General
Prognostic Factors
  • Often presents at late stage
  • Considered a poor prognostic variant due to more aggressive clinical course
  • Associated with higher rate of pleural invasion, nodal, intra- and extra-pulmonary metastasis
Case Reports
Gross Images
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Gray white tumor

Micro Description
  • Either papillary tufts without fibrovascular core connected to alveolar walls or a detached shedding tumor within alveolar spaces
  • Also ring-like glandular structures within alveolar spaces and psammoma bodies
Micro Images
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Micropapillary component

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Stromal micropapillary pattern

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Papillary and micropapillary structures

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Resected lymph node

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E cadherin, CD44

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MUC1, D240, CD34

Positive Stains
  • Has typical lung adenocarcinoma immunoprofile of CK7 (+), CK20 (-), TTF1 (+), and NapsinA (+)
Molecular / Cytogenetics Description
Additional References