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Lung tumor

Benign tumors

Paraganglioma


Reviewer: Deepali Jain, M.D. (see Reviewers page)
Revised: 8 January 2013, last major update September 2012
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.

General
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● Rare neuroendocrine tumor in lung; usually benign behavior
● May be hyperplastic, not neoplastic

Case reports
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● 37 year old woman (Korean J Radiol 2008;9:87)
● 69 year old woman with lung metastasis from bilateral carotid body paragangliomas (Interact Cardiovasc Thorac Surg 2004;3:578)

Gross description
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● Solitary or multiple, usually peripheral mass, often microscopic

Micro description
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● Zellballen pattern (islands of cells) with sustentacular cells at periphery of nests (Am J Surg Pathol 2004;28:825)

Micro images
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60 year old woman with primary pulmonary paraganglioma (left to right): H&E, chromogranin, synaptophysin, NSE, S100


Carotid body paragangliomas

Positive stains
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● Neuroendocrine markers
● S100 (sustentacular cells)

Negative stains
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● Keratin, mucin, CEA

Electron microscopy description
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● Resembles meningeal arachnoid granulations, dense core granules with an eccentric halo ("norepinephrine-type" granules)

Differential diagnosis
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Carcinoid tumor: ribbons, festoons, rosettes

End of Lung tumor > Benign tumors > Paraganglioma


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