Lung tumor
Lymphohistiocytic
Waldenström macroglobulinemia


Topic Completed: 1 September 2012

Revised: 22 October 2019

Copyright: 2003-2019, PathologyOutlines.com, Inc.

PubMed Search: Waldenstrom macroglobulinemia pulmonary

Deepali Jain, M.D.
Page views in 2018: 663
Page views in 2019 to date: 738
Table of Contents
Definition / general | Diagnosis
Cite this page: Jain D. Waldenström macroglobulinemia. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/lungtumorwaldenstrom.html. Accessed December 14th, 2019.
Definition / general
  • B-cell neoplasm (usually lymphoplasmacytic lymphoma) plus serum IgM monoclonal paraprotein
  • Usually elderly patients with indolent clinical course
  • Median survival 5 years
  • Involves bone marrow (100%), liver, spleen, lymph nodes (15 - 20%); lung is an unusual site (Am J Surg Pathol 2003;27:1104)
  • Hyperviscosity syndrome in 15%
Diagnosis
  • Serum protein electrophoresis to detect monoclonal paraprotein
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