Lymph nodes - not lymphoma
Neoplasms (not lymphoma)
Follicular dendritic cell sarcoma

Topic Completed: 1 June 2006

Revised: 5 February 2019

Copyright: (c) 2003-2018,, Inc.

PubMed Search: Follicular dendritic cell sarcoma[TI] lymph node

Page views in 2018: 3,827
Page views in 2019 to date: 3,961
Cite this page: DePond W. Follicular dendritic cell sarcoma. website. Accessed October 22nd, 2019.
Definition / general
  • Also called follicular dendritic cell tumor
  • Rare, first characterized in 1986 (Am J Pathol 1986;122:562)
  • Often presents as mass or cervical or other superficial lymph nodes of adults but may involve other nodal or extranodal sites (intra-abdominal, oral or from soft tissue)
  • May be associated with inflammatory pseudotumor of liver or hyaline vascular variant of Castleman disease
  • Recurs locally and metastasizes to liver and lung
  • Intraabdominal tumors are more aggressive
  • Immunostains are essential for diagnosis
Case reports
Microscopic (histologic) description
  • Fascicles, whorls or slight storiform patterns
  • Cells may appear syncytial due to interwoven cell processes
  • Cells are oval / spindle, with pseudonuclear inclusions, oval nuclei with vesicular chromatin and small nucleoli
  • Scattered small lymphocytes (T cells)
  • Often perivascular lymphocyte cuffing
  • Stroma may be myxoid
  • Occasional multinucleated giant cells, no / rare mitotic activity
Microscopic (histologic) images

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Various images


Negative stains
Electron microscopy description
  • Well developed, long cytoplasmic processes joined by desmosomes
  • No Birbeck granules
Electron microscopy images

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