Table of Contents
Definition / general | Diagnosis | Treatment | Microscopic (histologic) description | Microscopic (histologic) images | Electron microscopy description | Differential diagnosisCite this page: DePond W. Lymphogranuloma venereum. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/lymphnodesLGV.html. Accessed September 30th, 2020.
Definition / general
- Sexually transmitted disease caused by Chlamydia trachomatis serotypes L1, L2 and L3 (Mod Pathol 1995;8:924, MedlinePlus: Lymphogranuloma venereum [Accessed 3 July 2018], eMedicine: Lymphogranuloma Venereum (LGV) in Emergency Medicine [Accessed 3 July 2018], Wikipedia: Lymphogranuloma venereum [Accessed 3 July 2018])
- Endemic in tropical areas, rare in industrialized countries
- Outbreaks in Western Europe among male homosexuals (Rev Prat 2005;55:1747), in Bahamas associated with crack cocaine and HIV (Sex Transm Dis 2002;29:253)
- Three clinical stages (see references)
Diagnosis
- PCR
- Previously Frei test (delayed hypersensitivity skin test using "lygranum" chlamydial antigen)
Treatment
- Doxycycline for 21 days
Microscopic (histologic) description
- Early - tiny necrotic foci with neutrophils
- Late - stellate abscesses surrounded by pale epithelioid cells
- Abscesses may merge and sinus tracts may develop
- Macrophages may have organisms within vacuoles
Microscopic (histologic) images
Contributed by Dr. Mark R. Wick
Lymphogranuloma venereum
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Site unknown: various images
Electron microscopy description
- Elementary and reticulate bodies
Differential diagnosis
