Lymph nodes & spleen, nonlymphoid
Lymph nodes-general

Topic Completed: 1 June 2013

Minor changes: 30 September 2020

Copyright: 2003-2020,, Inc.

PubMed Search: Macrophages [title] lymph nodes [title]

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Cite this page: DePond WD. Macrophages. website. Accessed October 20th, 2020.
Definition / general
  • Process antigens via phagocytosis
  • Related to circulatory monocytes
  • Are present throughout the lymph node
  • May contain thyroglobulin in lymph nodes draining thyroid tumors (J Clin Pathol 2001;54:314)
Microscopic (histologic) description
  • Abundant cytoplasm with medium to large nuclei with vesicular chromatin
  • Tingible body macrophages have clear cytoplasm and contain apoptotic bodies, which gives node a starry sky pattern
Microscopic (histologic) images

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Macrophages (with pigment) and plasma cells

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Thyroglobulin+ histiocytes

Positive stains
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