Lymph nodes - not lymphoma
Age related changes
Reviewer: William D. DePond, M.D. (see Reviewers page)
Revised: 29 July 2013, last major update June 2006
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.
- Germinal centers are more common in infants and children, decrease in young adults, often absent in elderly ( Am J Pathol 1975;78:7)
- Germinal centers are more common in mesenteric and cervical lymph nodes ( J Clin Pathol 1980;33:454)
- Hyaline deposits increased with age
- Peripheral lymph nodes, with little antigenic stimulation, often have replacement by fat, particularly in axillary, cubital and popliteal nodes
- Lymphocyte depletion, fibrosis and hyaline deposits are associated with chronic disease, particularly cancer
Sclerosis in an inguinal lymph node
End of Lymph nodes - not lymphoma > Normal > Age related changes
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