Lymph nodes & spleen, nonlymphoid
Lymph nodes-general
Age related changes-lymph nodes

Topic Completed: 1 July 2013

Minor changes: 4 August 2020

Revised: 1 February 2019, last major update July 2013

Copyright: 2003-2020,, Inc.

PubMed Search: Age related changes [title] lymph nodes

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Page views in 2020 to date: 486
Cite this page: DePond W. Age related changes-lymph nodes. website. Accessed September 21st, 2020.
Definition / general
  • Germinal centers are more common in infants and children, decrease in young adults, often absent in elderly ( Am J Pathol 1975;78:7)
  • Germinal centers are more common in mesenteric and cervical lymph nodes ( J Clin Pathol 1980;33:454)
  • Hyaline deposits increased with age
  • Peripheral lymph nodes, with little antigenic stimulation, often have replacement by fat, particularly in axillary, cubital and popliteal nodes
  • Lymphocyte depletion, fibrosis and hyaline deposits are associated with chronic disease, particularly cancer
Microscopic (histologic) images

AFIP images

Sclerosis in an inguinal lymph node

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