Lymph nodes - not lymphoma
Age related changes

Author: William D. DePond, M.D. (see Authors page)

Revised: 21 June 2018, last major update July 2013

Copyright: (c) 2003-2018,, Inc.

PubMed Search: Age related changes [title] lymph nodes

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Cite this page: DePond, W. D. Normal: age related changes. website. Accessed January 21st, 2019.
Definition / general
  • Germinal centers are more common in infants and children, decrease in young adults, often absent in elderly ( Am J Pathol 1975;78:7)
  • Germinal centers are more common in mesenteric and cervical lymph nodes ( J Clin Pathol 1980;33:454)
  • Hyaline deposits increased with age
  • Peripheral lymph nodes, with little antigenic stimulation, often have replacement by fat, particularly in axillary, cubital and popliteal nodes
  • Lymphocyte depletion, fibrosis and hyaline deposits are associated with chronic disease, particularly cancer
Microscopic (histologic) images

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Sclerosis in an inguinal lymph node