Lymph nodes - not lymphoma
Inflammatory disorders (noninfectious)
Allergic granulomatosis

Author: Jaya Balakrishna, M.D. (see Authors page)
Editor: Abdelsalam Sharabi, M.D.

Revised: 29 June 2018, last major update January 2016

Copyright: (c) 2003-2018, PathologyOutlines.com, Inc.

PubMed Search: Allergic granulomatosis[TI]
Cite this page: Balakrishna, J. Allergic granulomatosis. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/lymphnodesallergicgranulomatosis.html. Accessed August 17th, 2018.
Definition / general
  • Allergic granulomatosis is a rare disorder of obscure etiology characterized by infiltration of lymph nodes with histiocytic granulomas and eosinophils
  • Due to isolated lymph node involvement by Churg-Strauss syndrome; also lymph node involvement by polyarteritis nodosa, granulomatous vasculitis (previously Wegener granulomatosis) or lupus erythematous
Essential features
  • Necrotizing granulomas
  • Eosinophils
  • Immunohistochemistry typical of reactive lymph node
  • Special stains for microorganisms negative
Terminology
  • Noninfectious necrotizing granulomatosis
Pathophysiology
  • Allergic reaction
Clinical features
  • Lymphadenopathy
  • Asthma and allergic sinusitis
Diagnosis
  • Microscopy
Laboratory
  • Nonspecific
  • Elevated IgE
  • Eosinophilia
Radiology description
  • Lymphadenopathy
Prognostic factors
  • Good response to steroid therapy
Case reports
Treatment
  • Steroids
Gross description
  • Enlarged lymph node
Microscopic (histologic) description
  • Conspicuous necrosis with eosinophilia and vasculitis
  • Vasculitis
  • Vessels may show sclerotic thickening
  • Epithelioid granulomas
  • Florid follicular hyperplasia
Microscopic (histologic) images

Images hosted on other servers:
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Eosinophilic vasculitis

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Lymph node architecture

Positive stains
  • Preserved B cell as well as T cell areas typical of a reactive lymph node
Negative stains
  • Special stains / immunostains for microorganisms