Lymph nodes - not lymphoma
Neoplasms (not lymphoma)
Angiomyomatous hamartoma




Topic Completed: 1 January 2014

Revised: 5 February 2019

Copyright: (c) 2003-2018, PathologyOutlines.com, Inc.

PubMed Search: Angiomyomatous hamartoma



Patricia Tsang, M.D., M.B.A.
Page views in 2018: 2,119
Page views in 2019 to date: 1,260
Cite this page: Tsang P. Angiomyomatous hamartoma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/lymphnodesangiomyomatoushamartoma.html. Accessed June 17th, 2019.
Definition / general
  • First described by Chan et al. in 1992 (Am J Surg Pathol 1992;16:335)
  • Rare and benign vascular disorder due to proliferation of blood vessels and smooth muscle in lymph nodes, often of long duration
Sites
Pathophysiology
  • Unknown etiology; may represent reparative reaction to previous nodal inflammation
Clinical features
  • Usually males, all ages
  • Benign clinical course
  • Local excision is curative
  • No known recurrence or metastasis
Case reports
Gross description
  • Enlarged and matted lymph nodes replaced by firm, white tissue
Gross images

Images hosted on PathOut server:

Replacement by tan, firm tissue

Microscopic (histologic) description
  • Extensive and multifocal nodal involvement by thick walled hilar blood vessels, often with increased fibrous tissue
  • Nodal parenchyma has haphazard smooth muscle cells in sclerotic stroma
  • Starts in nodal hilum and extends toward cortex
  • May have admixed adipose tissue
  • No cellular pleomorphism, no necrosis, low mitotic rate
Microscopic (histologic) images

Images hosted on PathOut server:

AFIP images:

Various images



Case of the Week #118:

CD3

CD20



Images hosted on other servers:

Various images show smooth muscle fibers, benign spindle cells


Benign adipocyte lobules

Desmin+ smooth muscle

CD34

Immunohistochemistry
Differential diagnosis
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