Lymph nodes - not lymphoma
Neoplasms (not lymphoma)

Topic Completed: 1 January 2014

Minor changes: 7 April 2020

Copyright: 2003-2020,, Inc.

PubMed Search: Angiosarcoma lymph nodes

Patricia Tsang, M.D., M.B.A.
Page views in 2019: 405
Page views in 2020 to date: 168
Cite this page: Tsang P. Angiosarcoma. website. Accessed May 27th, 2020.
Definition / general
  • Almost always represents metastatic disease to lymph node
  • May represent regional or distant metastasis
  • Originates from malignant endothelial cells
Clinical features
  • Nodal metastasis reported in 13.5% of angiosarcomas (Ann Surg 1993;217:72)
  • Incidence of nodal spread is relatively high compared to other sarcoma types
  • Aggressive tumor with poor prognosis
Case reports
  • Radical lymphadenectomy for isolated regional metastasis
Microscopic (histologic) description
  • Anastomosing vascular channels lined by anaplastic tumor cells
  • May be papillary
  • Infiltrative borders
Microscopic (histologic) images

Metastatic to lymph node

Positive stains
Negative stains
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