Lymph nodes - not lymphoma
Infectious / parasitic disorders
bCG



Topic Completed: 1 July 2013

Revised: 1 February 2019, last major update July 2013

Copyright: (c) 2003-2018, PathologyOutlines.com, Inc.

PubMed Search: bCG [title] lymph nodes [title]


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Cite this page: DePond W. bCG. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/lymphnodesbcg.html. Accessed October 22nd, 2019.
Definition / general
  • Post vaccination bacille Calmette-Guerin infection occurs in 1% of infants, although swelling usually subsides (Braz J Med Biol Res 2004;37:697)
  • Patients with normal immunity have complete recovery after postvaccination bCG infection after excision of infected lymph node; immunosuppressed patients may require antiTB therapy to avoid fatal disseminated infection (Am J Clin Pathol 2000;113:703)
Case reports
Treatment
Microscopic (histologic) description
  • Patients with normal immunity: multiple epithelioid granulomas and Langhans giant cells; variable suppuration, minimal caseous necrosis, few acid fast bacteria identified with Ziehl-Neelsen stain
  • Immunosuppressed patients: histiocytes with abundant gray cytoplasm containing numerous acid fast bacilli, plump nuclei
Microscopic (histologic) images

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Macrophages and neutrophils in necrotic background

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Ziehl-Neelsen stain
shows intra and
extracellular bacilli

Cytology description
  • Poorly to moderately cellular smears of epithelioid histiocytes in a granuloma pattern with occasional multinucleated Langerhans type giant cells, lymphocytes and neutrophils
  • Background is finely granular with necrotic debris
  • Isolated calcified spherules (Diagn Cytopathol 2001;25:134)
  • May be heavy involvement of acid fast bacilli (World J Surg Oncol 2003;1:25)
Additional references
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