Lymph nodes & spleen, nonlymphoid
Lymph nodes-infectious / parasitic disorders

Topic Completed: 1 June 2013

Minor changes: 21 July 2020

Revised: 1 February 2019, last major update June 2013

Copyright: 2003-2020,, Inc.

PubMed Search: Coccidioides immitis [title] lymph nodes

Page views in 2019: 671
Page views in 2020 to date: 336
Cite this page: DePond W. Coccidioides. website. Accessed September 28th, 2020.
Definition / general
  • Also called San Jaquin Valley Fever
  • Dimorphic fungus with distinct yeast and mold stages
  • Endemic to Lower Sonoran Desert (southwest US, Central and South America)
  • Usually self limiting, but more severe disease in immunocompromised hosts
Case reports
  • Culture (grows on all media)
  • Has enteroarthric conidia (alternating segments of hyphae undergo autolysis, while surviving segments form infective barrel shaped multinucleate arthroconidia)
Microscopic (histologic) description
  • Thick walled spherules 20 - 150 microns containing 3 - 5 micron endospores, surrounded by a giant cell granulomatous reaction
Microscopic (histologic) images

Images hosted on other servers:
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Figure 1: CT scan
2: H&E shows spherules filled with endospores
3: wooly white mold on blood agar plate after 5 days
4: Lacto-phenol cotton blue stain shows characteristic
enteroarthric conidia formation

Not necessarily lymph node
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Large spherules

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Various images

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