Lymph nodes - not lymphoma
Inflammatory disorders (non-infectious)
Dermatopathic lymphadenitis

Authors: William D. DePond, M.D. (see Authors page)

Revised: 27 July 2016, last major update June 2006

Copyright: (c) 2003-2016, PathologyOutlines.com, Inc.

PubMed search: Dermatopathic lymphadenitis
Definition / General
  • Also called lipomelanosis reticularis of Pautrier
  • Nodal hyperplasia secondary to generalized dermatitis, particularly with exfoliation
  • May occur in any skin disorder with itching and scratching
  • No features, other than tumor cells, predict associated mycosis fungoides (Am J Surg Pathol 1981;5:343)
  • In Japanese patients, associated with fever and multicentricity in most cases; less commonly with autoimmune disease, drug hypersensitivity reactions or angioimmunoblastic T cell lymphoma (Int J Surg Pathol 2004;12:127)
  • Rarely occurs with no clinical skin disease (Arch Pathol Lab Med 1988;112:1145)
Case Reports
Gross Description
  • Enlarged lymph node with bulging, yellow cut surface
  • Black pigment (melanin) may be present
Micro Description
  • Nodular expansion of interfollicular region due to histiocytes containing melanin pigment and fat, Langerhans cells and interdigitating dendritic cells
  • Often prominent post-capillary venules, plasma cells, follicular hyperplasia, eosinophils
Micro Images

Images hosted on PathOut server:

Case of the Week #396:

H&E images


CD1a+

CD3

CD20

S100+



Other images:

Contributed by Dr. Mark R. Wick

Dermatopathic lymphadenopathy

In a patient with Mycosis fungoides



Images hosted on other servers:

Various images

Dendritic cells are CAM 5.2+