Lymph nodes - not lymphoma
Neoplasms (not lymphoma)
Fibroblastic reticulum cell sarcoma



Topic Completed: 1 May 2014

Revised: 5 February 2019

Copyright: (c) 2003-2018, PathologyOutlines.com, Inc.

PubMed Search: Fibroblastic reticulum cell sarcoma


Patricia Tsang, M.D., M.B.A.
Page views in 2018: 496
Page views in 2019 to date: 492
Cite this page: Tsang P. Fibroblastic reticulum cell sarcoma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/lymphnodesfibroblasticreticulumcellsarcoma.html. Accessed November 13th, 2019.
Definition / general
  • Rare malignant neoplasm of nodal stromal cells
Pathophysiology
  • Arises from fibroblastic reticular cells in the T cell zone of the nodal cortex
  • Fibroblastic reticular cells secrete chemokines (interleukin 7 and CCL19) responsible for naive T cell survival (Nat Immunol 2007;8:1255)
Case reports
  • 25 year old man with reticulum cell sarcoma of lymph node with mixed dendritic and fibroblastic features (Mod Pathol 2001;14:1059)
  • 71 year old woman with tumor of fibroblastic reticular cells of lymph node coincidental with an undifferentiated endometrial stromal sarcoma (APMIS 2011;119:216)
Treatment
  • Surgery
Microscopic (histologic) description
  • Storiform or fascicular pattern of oval to spindle cells in a collagenized background
Microscopic (histologic) images

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Breast

VCAM1, CD40

Cytology images

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Wright stain

Positive stains
Negative stains
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