Lymph nodes & spleen, nonlymphoid
Lymph nodes-infectious / parasitic disorders

Topic Completed: 1 July 2013

Minor changes: 3 April 2020

Revised: 4 February 2019, last major update July 2013

Copyright: 2003-2020,, Inc.

PubMed Search: HHV8 [title] lymph nodes

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Table of Contents
Definition / general
Cite this page: DePond W. HHV8/KHSV. website. Accessed September 21st, 2020.
Definition / general
  • Human herpesvirus 8 / Kaposi sarcoma associated herpesvirus
  • High prevalence in East Africa
  • Associated with Kaposi sarcoma (Mod Pathol 2004;17:456); in endemic regions of Africa, association is independent of HIV status (Hum Pathol 2006;37:23)
  • Also associated with primary effusion lymphoma, plasmablastic lymphoma, some cases of multicentric Castleman disease
  • Note: most lymphomas are HHV8-, even in HHV8+ patients
  • Not associated with Kikuchi disease (Hum Pathol 2003;34:130), despite earlier study to the contrary (Hum Pathol 1998;29:1091)
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