Lymph nodes & spleen, nonlymphoid
Lymph nodes-infectious / parasitic disorders
Herpes simplex

Topic Completed: 1 July 2013

Minor changes: 29 July 2020

Revised: 4 February 2019, last major update July 2013

Copyright: 2003-2020,, Inc.

PubMed Search: Herpes simplex [title] lymph nodes [title]

Page views in 2019: 333
Page views in 2020 to date: 328
Cite this page: DePond W. Herpes simplex. website. Accessed September 21st, 2020.
Definition / general
Case reports
Microscopic (histologic) description
  • Well circumscribed necrosis, follicular and paracortical hyperplasia (Histopathology 1991;19:355)
  • Cells have intranuclear inclusions, particularly at edge of necrotic areas
  • Also marked immunoblasts, T cell hyperplasia
Microscopic (histologic) images

Contributed by Dr. Mark R. Wick
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Herpes simplex lymphadenitis

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Parafollicular expansion

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Various images of tonsillar HSV infection

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Figure 2: HSV inclusions
Figure 4: HSV1/2 immunostain

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Interfollicular infiltrate of immunoblasts,
centroblasts, small lymphocytes
and occasional histiocytes and venule
with prominent endothelial cells

Positive stains
  • HSV
Electron microscopy description
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Image 01 Image 02