Lymph nodes & spleen, nonlymphoid
Lymph nodes-inflammatory disorders
Inflammatory pseudotumor

Topic Completed: 1 June 2006

Minor changes: 10 August 2020

Copyright: 2003-2020,, Inc.

PubMed Search: Inflammatory pseudotumor[TI] lymph node

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Cite this page: DePond W. Inflammatory pseudotumor. website. Accessed August 12th, 2020.
Definition / general
  • One or many lymph nodes are affected
  • Often fever, anemia, elevated erythrocyte sedimentation rate, hypergammaglobulinemia, prominent lymphadenopathy
  • Usually benign / reactive, not neoplastic and so distinct from inflammatory myofibroblastic tumor at this site (Hum Pathol 2001;32:1382)
Case reports
  • Steroids, NSAIDs
Microscopic (histologic) description
  • Varies from case to case
  • Storiform pattern of spindled fibroblasts or myofibroblasts in fibrous stroma of node with extension into lymphoid tissue and perinodal tissue
  • Vascular proliferation and mixed inflammatory infiltrate of plasma cells, immunoblasts, small lymphocytes, histiocytes, dendritic cells, neutrophils and fibroblasts
Microscopic (histologic) images

AFIP images

Inflammatory pseudotumor of lymph node

Contributed by Dr. Mark R. Wick

Images hosted on other servers:

Tumor has hilar location in node

Spindle cells, plasma
cells, lymphocytes
and vascular

Interface between calcified tumor and lymph node

Hyalinized collagenous
tissue with psammoma
bodies and scattered
spindle cells

A: perivascular fibrosis
B: perivascular hyalinization of small vessels
C: intravascular fibrin thrombi
D: transmural lymphocytic infiltrate in pericapsular vessel

Cytology description
Negative stains
Molecular / cytogenetics description
  • No clonal T cell receptor gene rearrangements
Differential diagnosis
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