Lymph nodes - not lymphoma
Neoplasms (not lymphoma)
Interdigitating dendritic cell / reticulum cell sarcoma

Author: William D. DePond, M.D. (see Authors page)

Revised: 25 June 2018, last major update June 2006

Copyright: (c) 2003-2018,, Inc.

PubMed Search: Interdigitating dendritic cell reticulum cell sarcoma lymph nodes

Cite this page: DePond, W.D. Interdigitating dendritic cell / reticulum cell sarcoma. website. Accessed August 17th, 2018.
Definition / general
  • Also called interdigitating dendritic cell tumor
  • Very rare
  • Usually arises in lymph nodes with widespread lymphadenopathy but also in bladder, bowel, intestine, nasopharynx, salivary glands, skin, spleen, testis and tonsils
  • Aggressive behavior, with half dying of disease after an average of 7 months
  • Have same morphologic and immunohistochemical features as nonneoplastic interdigitating dendritic cells
  • Presence of another hematologic neoplasm is common
Case reports
Microscopic (histologic) description
  • Fascicles or whorls of paracortical tumor cells that spare the follicles and sinuses
  • Tumor cells are large and pleomorphic with abundant pale, eosinophilic cytoplasm and bizarre, grooved nuclei
  • May have tumor giant cells, mitotic activity, inflammatory infiltrate
Microscopic (histologic) images

Images hosted on PathOut server:

Various images

Images hosted on other servers:

With SLL

Duodenal tumor with nodal metastases

Negative stains
Electron microscopy description
  • Interdigitating cytoplasmic processes but no desmosomes or other junctional complexes, no Birbeck granules
Additional references