Lymph nodes - not lymphoma
Inflammatory disorders (noninfectious)
Kimura disease

Author: William D. DePond, M.D. (see Authors page)

Revised: 28 June 2018, last major update June 2006

Copyright: (c) 2003-2018,, Inc.

PubMed Search: Kimura disease[TI]

Cite this page: DePond, W.D. Kimura disease. website. Accessed December 15th, 2018.
Definition / general
  • Chronic inflammatory disorder of unknown etiology
  • Endemic in Asia, affects young men
  • Often subcutaneous mass of head and neck (including salivary glands), associated with regional lymphadenopathy but normal overlying skin
  • Lesions persist and may recur after excision
Case reports
  • Excision, radiation therapy, cyclosporine
Microscopic (histologic) description
  • Germinal center hyperplasia with polykaryocytes, fibrosis and proteinaceous material in germinal centers
  • Folliculolysis, interfollicular eosinophils and eosinophilic abscesses
  • Increased paracortical plasma cells
  • Variable hyalinized vessels
  • Soft tissue lesions show proliferation of thin walled vessels with eosinophilia
Microscopic (histologic) images

Images hosted on other servers:

Skin: various images

Cytology description
  • Polymorphous lymphoid population with significant eosinophils, fragments of collagenous tissue, endothelial cells and occasional polykaryocytes (Acta Cytol 2002;46:357)
Positive stains
Molecular / cytogenetics description
  • May be clonal rearrangement of T cell receptor delta gene
Differential diagnosis