Lymph nodes & spleen, nonlymphoid
Lymph nodes-inflammatory disorders
Mantle cell / marginal zone hyperplasia

Topic Completed: 1 June 2006

Revised: 5 February 2019, last major update June 2006

Copyright: (c) 2003-2018,, Inc.

PubMed Search: Mantle cell marginal zone hyperplasia

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Page views in 2020 to date: 484
Cite this page: DePond W. Mantle cell / marginal zone hyperplasia. website. Accessed July 13th, 2020.
Definition / general
  • Gene rearrangement studies and followup recommended to rule out occult lymphoma in cases with clear cells (Am J Clin Pathol 2001;116:550)
  • Marginal zone hyperplasia is rare (except in mesenteric nodes) but does occur in reactive nodes (APMIS 2002;110:325)
Microscopic (histologic) description
  • Monomorphic proliferation of small lymphocytes with clear cytoplasm and round nuclei
  • No pericapsular infiltration, sinuses are identifiable, scattered reactive follicles
Microscopic (histologic) images

Images hosted on PathOut server:

Contributed by Dr. Mark R. Wick:

Cortical hyperplasia

Positive stains
Negative stains
  • No light chain restriction
Molecular / cytogenetics description
  • Usually negative
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