Lymph nodes - not lymphoma
Inflammatory disorders (noninfectious)
Mantle cell / marginal zone hyperplasia

Author: William D. DePond, M.D. (see Authors page)

Revised: 28 June 2018, last major update June 2006

Copyright: (c) 2003-2018,, Inc.

PubMed Search: Mantle cell marginal zone hyperplasia

Cite this page: DePond, W.D. Mantle cell / marginal zone hyperplasia. website. Accessed August 17th, 2018.
Definition / general
  • Gene rearrangement studies and followup recommended to rule out occult lymphoma in cases with clear cells (Am J Clin Pathol 2001;116:550)
  • Marginal zone hyperplasia is rare (except in mesenteric nodes) but does occur in reactive nodes (APMIS 2002;110:325)
Microscopic (histologic) description
  • Monomorphic proliferation of small lymphocytes with clear cytoplasm and round nuclei
  • No pericapsular infiltration, sinuses are identifiable, scattered reactive follicles
Microscopic (histologic) images

Images hosted on PathOut server:

Contributed by Dr. Mark R. Wick:

Cortical hyperplasia

Positive stains
Negative stains
  • No light chain restriction
Molecular / cytogenetics description
  • Usually negative