Lymph nodes - not lymphoma
Inflammatory disorders (non-infectious)
Mantle cell / marginal zone hyperplasia
Reviewer: William D. DePond, M.D. (see Reviewers page)
Revised: 26 July 2013, last major update June 2006
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.
- Gene rearrangement studies and followup recommended to rule out occult lymphoma in cases with clear cells (Am J Clin Pathol 2001;116:550)
- Marginal zone hyperplasia is rare (except in mesenteric nodes), but does occur in reactive nodes (APMIS 2002;110:325)
- Monomorphic proliferation of small lymphocytes with clear cytoplasm and round nuclei
- No pericapsular infiltration, sinuses are identifiable, scattered reactive follicles
Cortical hyperplasia - contribtued by Dr. Mark R. Wick
- No light chain restriction
End of Lymph nodes - not lymphoma > Inflammatory disorders (non-infectious) > Mantle cell / marginal zone hyperplasia
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