Lymph nodes - not lymphoma
Neoplasms (excludes lymphoma)
Mastocytosis

Author: Sheren Younes, M.D. (see Authors page)

Revised: 25 March 2016, last major update March 2016

Copyright: (c) 2003-2016, PathologyOutlines.com, Inc.
Definition / General
  • Systemic disease that often involves lymph nodes, but only rarely presents with lymphadenopathy (Cesk Patol 2006;42:34)
  • The most common category of mastocytosis that involves lymph nodes is indolent systemic mastocytosis
  • See chapters on bone and spleen for more extensive discussion
Case Reports
Micro Description
  • Variable effacement of nodal architecture by monotonous round / polygonal cells with distinct cell membranes, clear / granular cytoplasm, round / oval nuclei, eosinophils
  • Associated with sclerosis
  • Cells often have perifollicular, perivascular or interfollicular distribution
  • May have prominent vascular proliferation
  • Starts at paracortex and medullary cords, follicles are usually intact
  • Infiltration by mast cells with accompanying eosinophiils and variable fibrosis
  • Cells have abundant cytoplasm, which is granular / clear
  • Nuclei are round / indented
Micro Images
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Systemic mastocytosis

Systemic mastocytosis

Systemic mastocytosis

Systemic mastocytosis

Systemic mastocytosis

Involving bone marrow

Systemic mastocytosis


Images hosted on other servers:

Figure 1: bone marrow, 2: spleen, 3: lymph node (sinusoidal involvement)

Cytology Images
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Cytologic spectrum

Positive Stains
  • Highlighting mast cell granules:
  • Differential Diagnosis