Lymph nodes - not lymphoma
Neoplasms (not lymphoma)

Author: Sheren Younes, M.D. (see Authors page)

Revised: 22 June 2018, last major update March 2016

Copyright: (c) 2003-2018,, Inc.

PubMed Search: Mastocytosis[TI] lymph nodes

Cite this page: Younes, S. Mastocytosis. website. Accessed July 17th, 2018.
Definition / general
  • Systemic disease that often involves lymph nodes but only rarely presents with lymphadenopathy (Cesk Patol 2006;42:34)
  • Most common category of mastocytosis that involves lymph nodes is indolent systemic mastocytosis
  • See chapters on bone and spleen for more extensive discussion
Case reports
Microscopic (histologic) description
  • Variable effacement of nodal architecture by monotonous round / polygonal cells with distinct cell membranes, clear / granular cytoplasm, round / oval nuclei, eosinophils
  • Associated with sclerosis
  • Cells often have perifollicular, perivascular or interfollicular distribution
  • May have prominent vascular proliferation
  • Starts at paracortex and medullary cords, follicles are usually intact
  • Infiltration by mast cells with accompanying eosinophiils and variable fibrosis
  • Cells have abundant cytoplasm, which is granular / clear
  • Nuclei are round / indented
Microscopic (histologic) images

Images hosted on PathOut server:

Systemic mastocytosis

Involving bone marrow

Images hosted on other servers:

Fig 1: bone marrow
Fig 2: spleen
Fig 3: lymph node
(sinusoidal involvement)

Cytology images

Images hosted on PathOut server:

Cytologic spectrum

Positive stains
Differential diagnosis