Lymph nodes - not lymphoma
Inclusions, pigment, ectopic cells or tissue
Müllerian inclusions / cysts

Senior Author: Abdelsalam Sharabi, M.D.
Jayalakshmi Balakrishna, M.D.

Topic Completed: 1 July 2014

Revised: 1 February 2019, last major update July 2014

Copyright: (c) 2003-2018,, Inc.

PubMed Search: Müllerian inclusions and cysts

Jayalakshmi Balakrishna, M.D.
Page views in 2018: 787
Page views in 2019 to date: 894
Cite this page: Balakrishna J. Müllerian inclusions / cysts. website. Accessed October 13th, 2019.
Definition / general
  • Benign glandular inclusions lined by salpingeal or ovarian epithelium with no endometrial stroma or hemosiderophages
  • Also called endosalpingiosis
  • Theories include:
    • Passage of epithelial cells through the tubal ostium for implantation in the peritoneum following peeling, followed by transportation by the lymphatic route to reach the pelvic lymph node
    • Metaplastic origin from the peritoneum
    • Foci of endometriosis
    • Vestiges of paramesonephricus ducts
    • Metastases from ovarian serous borderline tumors (Am J Surg Pathol 2000;24:710)
Clinical features
  • Incidental finding / enlarged lymph nodes
Case reports
  • Benign process, with no clinical significance
Gross description
  • Enlarged lymph nodes
Microscopic (histologic) description
  • Glandular / cystic inclusions lined by cuboidal / columnar cells with a Müllerian or coelomic appearance commonly found in the capsule
  • Psammoma bodies are common
  • May undergo squamous metaplasia
  • No / rare mitotic figures, no / mild atypia, no desmoplastic stroma, no endometrial stroma
Microscopic (histologic) images

Images hosted on PathOut server:
Missing Image

In pelvic lymph node

Positive stains
Differential diagnosis
  • Metastasis from borderline / malignant ovarian tumors or uterine carcinomas
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