Lymph nodes - not lymphoma
Normal lymphocyte development
Reviewer: William D. DePond, M.D. (see Reviewers page)
Revised: 3 July 2013, last major update June 2006
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.
- Normal lymphoid cells undergo rearrangements within their antigen receptor genes, causing specificity for the immunoglobulin or T cell receptor that they produce
- Monoclonal proliferations are presumed to be neoplastic; polyclonal populations are not
- Apoptosis helps eliminate B cells producing antibodies with low avidity
- Lymphoid stem cell: TdT+, CD34+, HLA-DR+, then develops along B or T cell pathway
End of Lymph nodes - not lymphoma > Normal > Normal lymphocyte development
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