Lymph nodes - not lymphoma
Normal
Normal lymphocyte development



Topic Completed: 1 July 2013

Revised: 1 February 2019, last major update July 2013

Copyright: (c) 2003-2018, PathologyOutlines.com, Inc.

PubMed Search: Normal lymphocyte development [title]


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Table of Contents
Definition / general
Cite this page: DePond W. Normal: normal lymphocyte development. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/lymphnodesnormallymphocytedev.html. Accessed August 21st, 2019.
Definition / general
  • Normal lymphoid cells undergo rearrangements within their antigen receptor genes causing specificity for the immunoglobulin or T cell receptor that they produce
  • Monoclonal proliferations are presumed to be neoplastic; polyclonal populations are not
  • Apoptosis helps eliminate B cells producing antibodies with low avidity
  • Lymphoid stem cell: TdT+, CD34+, HLA-DR+, then develops along B or T cell pathway
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