Table of ContentsDefinition / general
Cite this page: DePond W. Normal: normal lymphocyte development. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/lymphnodesnormallymphocytedev.html. Accessed August 21st, 2019.
Definition / general
- Normal lymphoid cells undergo rearrangements within their antigen receptor genes causing specificity for the immunoglobulin or T cell receptor that they produce
- Monoclonal proliferations are presumed to be neoplastic; polyclonal populations are not
- Apoptosis helps eliminate B cells producing antibodies with low avidity
- Lymphoid stem cell: TdT+, CD34+, HLA-DR+, then develops along B or T cell pathway