Lymph nodes - not lymphoma
Infectious / parasitic disorders
Parvovirus B19




Topic Completed: 1 June 2006

Revised: 4 February 2019, last major update June 2006

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PubMed Search: Parvovirus B19 lymph node

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Cite this page: DePond W. Parvovirus B19. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/lymphnodesparvovirusB19.html. Accessed February 21st, 2019.
Definition / general
  • In adults, parvovirus B19 infection is associated with fever (81%), arthralgia / myalgia (62%), skin rash (48%), general fatigue (43%), lymphadenopathy (38%) and edema (38%) (Intern Med 2002;41:295)
  • May be associated with hemophagocytic syndrome (Br J Haematol 1997;96:868)
Diagnosis
  • PCR
  • Immunohistochemistry
Case reports
Microscopic (histologic) description
  • Massive nodular histiocytic proliferation resembling Kikuchi disease with prominent apoptosis but no necrosis
  • One case showed florid reactive hyperplasia with paracortical expansion, neutrophils and hemophagocytosis (Pathol Int 1998;48:829)
Microscopic (histologic) images

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Prominent nodules of histiocytes