Lymph nodes & spleen, nonlymphoid
Lymph nodes-nonlymphoid neoplasms

Topic Completed: 1 June 2006

Minor changes: 14 August 2020

Copyright: 2003-2020,, Inc.

PubMed Search: Plasmacytoma[TI] lymph nodes

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Cite this page: DePond W. Plasmacytoma. website. Accessed September 29th, 2020.
Definition / general
  • Very rare (< 50 reported cases)
  • Diagnosis of primary plasmacytoma of lymph node requires exclusion of extramedullary plasmacytoma (15% of upper respiratory tract plasmacytomas metastasize to cervical nodes) and myeloma (40% of high stage myelomas metastasize to nodes)
  • 2/3 male; median age 59 years (range 39 - 76 years)
  • Often involves cervical nodes
  • Similar survival to other extramedullary plasmacytomas, although does not progress to myeloma (Am J Clin Pathol 2001;115:119, Hum Pathol 1997;28:1083)
Case reports
  • Surgery and radiotherapy
Microscopic (histologic) description
  • Similar to plasmacytomas outside lymph node
  • Dense, monotonous infiltrate of plasma cells that effaces nodal architecture
  • Cells vary from mature to binucleated to anaplastic
  • Plasmablastic if amphophilic to basophilic cytoplasm with small Golgi zone and large vesicular nuclei with prominent central nucleoli
  • Anaplastic if marked pleomorphism and irregular foldings in nuclear membranes
  • May have amyloid deposits
Microscopic (histologic) images

AFIP images

Various images

With crystalloids

With amyloid deposition

With blood lakes

With myxoid stroma

Plasmablastic plasmacytoma of nasopharynx

Anaplastic plasmacytoma


Positive stains
  • Immunoglobulin light chain restriction
  • Usually positive for CD79a, EMA
  • Variable CD43 and CD45RO
Negative stains
Molecular / cytogenetics description
  • Negative for KSHV / HHV8
Differential diagnosis
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