Lymph nodes & spleen, nonlymphoid
Lymph nodes-nonlymphoid neoplasms
Plasmacytoma


Topic Completed: 1 June 2006

Minor changes: 14 August 2020

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PubMed Search: Plasmacytoma[TI] lymph nodes

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Cite this page: DePond W. Plasmacytoma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/lymphnodesplasmacytoma.html. Accessed September 29th, 2020.
Definition / general
  • Very rare (< 50 reported cases)
  • Diagnosis of primary plasmacytoma of lymph node requires exclusion of extramedullary plasmacytoma (15% of upper respiratory tract plasmacytomas metastasize to cervical nodes) and myeloma (40% of high stage myelomas metastasize to nodes)
  • 2/3 male; median age 59 years (range 39 - 76 years)
  • Often involves cervical nodes
  • Similar survival to other extramedullary plasmacytomas, although does not progress to myeloma (Am J Clin Pathol 2001;115:119, Hum Pathol 1997;28:1083)
Case reports
Treatment
  • Surgery and radiotherapy
Microscopic (histologic) description
  • Similar to plasmacytomas outside lymph node
  • Dense, monotonous infiltrate of plasma cells that effaces nodal architecture
  • Cells vary from mature to binucleated to anaplastic
  • Plasmablastic if amphophilic to basophilic cytoplasm with small Golgi zone and large vesicular nuclei with prominent central nucleoli
  • Anaplastic if marked pleomorphism and irregular foldings in nuclear membranes
  • May have amyloid deposits
Microscopic (histologic) images

AFIP images

Various images

With crystalloids

With amyloid deposition


With blood lakes

With myxoid stroma

Plasmablastic plasmacytoma of nasopharynx

Anaplastic plasmacytoma

Immunohistochemistry

Positive stains
  • Immunoglobulin light chain restriction
  • Usually positive for CD79a, EMA
  • Variable CD43 and CD45RO
Negative stains
Molecular / cytogenetics description
  • Negative for KSHV / HHV8
Differential diagnosis
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