Lymph nodes - not lymphoma
Primary immunodeficiency disorders

Topic Completed: 1 June 2013

Revised: 1 February 2019, last major update June 2013

Copyright: (c) 2003-2018,, Inc.

PubMed Search: Primary immunodeficiency disorders [title]

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Table of Contents
Definition / general
Cite this page: DePond W. Primary immunodeficiency disorders general. website. Accessed December 13th, 2019.
Definition / general
  • Either humoral (B cell related), cell mediated (T cell related) or defects in phagocytes / accessory immune system
  • Diagnosis requires laboratory testing (including immunoglobulins), delayed type skin reactions and lymphocyte testing
  • Lymph node biopsies provide quantitative information
  • Humoral based disease - medullary plasma cells and no / reduced cortical centers
  • Cell mediated based disease - reduced paracortical areas
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