Hematology
Primary immunodeficiency disorders
General



Topic Completed: 1 June 2013

Revised: 17 February 2020

Copyright: 2003-2020, PathologyOutlines.com, Inc.

PubMed Search: Primary immunodeficiency disorders [title]

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Table of Contents
Definition / general
Cite this page: DePond W. Primary immunodeficiency disorders - general. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/lymphnodesprimaryimmunodefgeneral.html. Accessed March 31st, 2020.
Definition / general
  • Either humoral (B cell related), cell mediated (T cell related) or defects in phagocytes / accessory immune system
  • Diagnosis requires laboratory testing (including immunoglobulins), delayed type skin reactions and lymphocyte testing
  • Lymph node biopsies provide quantitative information
  • Humoral based disease - medullary plasma cells and no / reduced cortical centers
  • Cell mediated based disease - reduced paracortical areas
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