Lymph nodes - not lymphoma
Primary immunodeficiency disorders

Author: William D. DePond, M.D. (see Authors page)

Revised: 28 June 2018, last major update June 2013

Copyright: (c) 2003-2018,, Inc.

PubMed Search: Primary immunodeficiency disorders [title]

Table of Contents
Definition / general
Cite this page: DePond, W. D. Primary immunodeficiency disorders general. website. Accessed July 16th, 2018.
Definition / general
  • Either humoral (B cell related), cell mediated (T cell related) or defects in phagocytes / accessory immune system
  • Diagnosis requires laboratory testing (including immunoglobulins), delayed type skin reactions and lymphocyte testing
  • Lymph node biopsies provide quantitative information
  • Humoral based disease - medullary plasma cells and no / reduced cortical centers
  • Cell mediated based disease - reduced paracortical areas