Table of ContentsDefinition / general | Case reports | Microscopic (histologic) description | Microscopic (histologic) images | Positive stains | Electron microscopy images | Differential diagnosis
Cite this page: DePond W. Prosthesis related changes. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/lymphnodesprosthesisrelated.html. Accessed June 1st, 2020.
Definition / general
- 76 year old woman with histiocytic lymphadenitis post shoulder joint replacement (Am J Clin Pathol 1993;99:314)
- 78 year old woman with right pelvic cystic mass due to chromium in hip prosthesis (Acta Cytol 2003;47:270)
- Post hip replacement with coexisting metastatic prostate adenocarcinoma to same lymph node (Hum Pathol 1998;29:95)
Microscopic (histologic) description
- Sinuses distended by large macrophages with abundant granular PAS+ eosinophilic cytoplasm representing polyethylene (Am J Surg Pathol 1989;13:1050)
- May contain black specks which resemble "dirt"
- Pelvic lymph nodes in patients with cobalt-chromium or titanium hip implants may have heavy metal microparticles or polyethylene particles with associated florid sinus histiocytosis (Am J Surg Pathol 1994;18:83)
Microscopic (histologic) images
- PAS+ polyethylene particles