Lymph nodes & spleen, nonlymphoid
Lymph nodes-inclusions, pigment, ectopic cells or tissue
Prosthesis related

Topic Completed: 1 July 2013

Minor changes: 14 August 2020

Copyright: 2003-2020,, Inc.

PubMed Search: Prosthesis related changes lymph nodes

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Cite this page: DePond W. Prosthesis related. website. Accessed October 26th, 2020.
Definition / general
Case reports
Microscopic (histologic) description
  • Sinuses distended by large macrophages with abundant granular PAS+ eosinophilic cytoplasm representing polyethylene (Am J Surg Pathol 1989;13:1050)
  • May contain black specks which resemble "dirt"
  • Pelvic lymph nodes in patients with cobalt-chromium or titanium hip implants may have heavy metal microparticles or polyethylene particles with associated florid sinus histiocytosis (Am J Surg Pathol 1994;18:83)
Microscopic (histologic) images

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Sinus histiocytosis
and histiocytes
with multiple
spindled particles

Positive stains
  • PAS+ polyethylene particles
Electron microscopy images

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Particles are 1 micron

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