Lymph nodes - not lymphoma
Inflammatory disorders (noninfectious)
Sjögren syndrome




Topic Completed: 1 June 2006

Revised: 5 February 2019, last major update June 2006

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PubMed Search: Sjögren syndrome[TIAB] lymph node

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Cite this page: DePond W. Sjögren syndrome. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/lymphnodessjogrenssyndrome.html. Accessed April 26th, 2019.
Definition / general
  • Associated with increased risk of lymphoma, usually B cell or low grade (MALT), may transform to aggressive large cell lymphoma
  • Evolution to lymphoma if architectural effacement and expanding clusters of monocytoid B cells or monotypic plasma cells
Microscopic (histologic) description
  • Follicular hyperplasia with interfollicular plasmacytosis
  • May have partial nodal effacement by interfollicular macrophages, plasma cells, immunoblasts and small lymphocytes
  • Sinuses may contain monocytoid B cells
Negative stains
  • Plasma cells are polyclonal
Differential diagnosis
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