Lymph nodes - not lymphoma
Infectious / parasitic disorders
Tuberculosis



Topic Completed: 1 June 2006

Revised: 4 February 2019, last major update June 2006

Copyright: (c) 2003-2018, PathologyOutlines.com, Inc.

PubMed Search: Tuberculosis[TI] lymph nodes[TI] full text[sb]

See also: Lung - nontumor chapter

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Cite this page: DePond W. Tuberculosis. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/lymphnodestb.html. Accessed December 6th, 2019.
Definition / general
  • Usually nodal involvement of cervical region (scrofula), often with draining sinus to skin
  • Generalized TB in AIDS cases at autopsy show thoracic or abdominal nodal involvement in almost all cases, although TB often not diagnosed prior to death (Arch Pathol Lab Med 2000;124:1267)
  • Needle biopsy of enlarged nodes may be helpful in smear negative, HIV+ patients with suspected TB (Int J Tuberc Lung Dis 2005;9:220)
Diagnosis
Case reports
Gross description
  • Large multinodular mass that resembles carcinoma with multiple foci of caseous necrosis
Gross images

Images hosted on PathOut server:

Contributed by Dr. Mark R. Wick:

Tuberculous lymphadenitis



Images hosted on other servers:

Multinodular mass

Microscopic (histologic) description
  • Either multiple small epithelioid granulomas or huge epithelioid granulomas with prominent Langhans giant cells and central necrosis (J Clin Pathol 1988;41:93)
Microscopic (histologic) images

Images hosted on PathOut server:

Contributed by Dr. Mark R. Wick:

Tuberculous lymphadenitis

Ziehl-Neelsen stain



Images hosted on other servers:

Granulomatous reaction

Noncaseous necrosis with prominent nuclear debris


Macrophages around foci of necrosis

With metastatic adenocarcinoma

Ziehl-Neelsen stain in HIV+ patient with TB

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