Lymph nodes - not lymphoma
Infectious / parasitic disorders

Topic Completed: 1 June 2006

Revised: 4 February 2019, last major update June 2006

Copyright: (c) 2003-2018,, Inc.

PubMed Search: Vaccinia lymph nodes

William D. DePond, M.D.
Page views in 2018: 32
Page views in 2019 to date: 31
Cite this page: DePond W. Vaccinia. website. Accessed June 17th, 2019.
Definition / general
  • Post smallpox vaccination may cause enlarged and painful adenopathy, up to 6 cm in 29% at 10 days (Vaccine 2006;24:476)
  • Usually supraclavicular nodes on side of vaccination
Microscopic (histologic) description
  • Paracortical expansion with eosinophils, plasma cells and immunoblasts
  • Vascular changes and focal necrosis
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