Cite this page: DePond W. Vaccinia. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/lymphnodesvaccinia.html. Accessed June 17th, 2019.
Definition / general
- Post smallpox vaccination may cause enlarged and painful adenopathy, up to 6 cm in 29% at 10 days (Vaccine 2006;24:476)
- Usually supraclavicular nodes on side of vaccination
Microscopic (histologic) description
- Paracortical expansion with eosinophils, plasma cells and immunoblasts
- Vascular changes and focal necrosis