Lymph nodes - not lymphoma
Inflammatory disorders (non-infectious)
Vascular transformation of sinuses

Authors: William D. DePond, M.D. (see Authors page)

Revised: 18 October 2016, last major update June 2006

Copyright: (c) 2003-2016, PathologyOutlines.com, Inc.

PubMed search: vascular transformation of sinuses
Cite this page: Vascular transformation of sinuses. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/lymphnodesvasculartransformationofsinuses.html. Accessed December 8th, 2016.
Definition / General
  • Also called nodal angiomatosis
  • Usually found incidentally after resection of a nearby tumor
  • Benign; all ages
  • Due to obstruction of lymphatic efferent vessels or venous obstruction (Arch Pathol Lab Med 1990;114:656), or perhaps other angiogenic factors
Case Reports
Micro Description
  • Subcapsular and medullary sinuses contain complex network of anastomosing blood vessels of variable sizes with fibrosis
  • May have irregularly branching vascular slits accompanied by pericytes with maturation towards well-formed vascular channels, may have extravasated red blood cells and interstitial fibrin deposits
  • Reactive, not neoplastic
  • May also have spindle cell nodules confined to sinus (associated with retroperitoneal nodes removed for renal cell carcinoma)
  • Lymphoid parenchyma may show atrophy
  • No atypia, no PAS+ hyaline globules, no capsular involvement
Micro Images

Images hosted on PathOut server:

Case of the Week #405:



Other images:

Various images

Vascular transformation of sinuses

Intra-abdominal lymph node

Nodular spindle cell vascular transformation

Differential Diagnosis
  • Kaposi sarcoma: involvement throughout lymph node including capsule, not just sinuses; well formed and curved spindle cell fascicles, vascular slits are nonbranching; atypia and PAS+ hyaline globules, no fibrosis, patients are HIV+ or African children (Am J Surg Pathol 1991;15:732)