Lymphoma and plasma cell neoplasms
B cell lymphoma subtypes
ALK-positive large B cell lymphoma

Topic Completed: 1 March 2011

Revised: 6 February 2019

Copyright: (c) 2001-2017,, Inc.

PubMed Search: ALK-positive large B cell lymphoma

Nikhil Sangle, M.D.
Page views in 2018: 1,124
Page views in 2019 to date: 728
Cite this page: Sangle N. ALK positive large B cell lymphoma. website. Accessed September 16th, 2019.
Definition / general
  • Very rare neoplasm of immunoblast-like ALK-positive B cells that lacks the t(2;5) translocation characteristic of anaplastic large cell lymphoma
  • Originates from post-germinal center B cells with plasma cell differentiation
Clinical features
  • Male predominance; median age = 36 years
  • Mediastinal and nodal involvement common
  • Poor prognosis; median survival for stage III / IV = 11 months
Microscopic (histologic) description
  • Sinusoidal pattern of lymph node involvement; immunoblastic and plasmablastic cells with abundant cytoplasm and round pale nuclei with prominent nucleoli
Positive stains
Negative stains
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