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Lymphoma - B cell neoplasms

B cell lymphoma subtypes

ALK-positive large B-cell lymphoma


Reviewer: Nikhil Sangle, M.D., University of Utah and ARUP Laboratories (see Reviewers page)
Revised: 20 March 2011, last major update March 2011
Copyright: (c) 2001-2011, PathologyOutlines.com, Inc.

Definition
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● Very rare neoplasm of immunoblast-like ALK-positive B-cells that lacks the t(2;5) translocation characteristic of anaplastic large cell lymphoma

Etiology
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● Originates from post-germinal center B cells with plasma cell differentiation

Clinical features
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● Male predominance; median age = 36 years
● Mediastinal and nodal involvement common
● Poor prognosis; median survival for stage III/IV = 11 months

Micro images
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● Sinusoidal pattern of lymph node involvement; immunoblastic and plasmablastic cells with abundant cytoplasm and round pale nuclei with prominent nucleoli

Positive stains
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● ALK, EMA, CD138, IgA/IgG, restricted light chain expression
● Also CD4, CD57 and IRF4/MUM1
● Variable cytokeratin

Negative stains
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● CD3, CD20, CD79a, CD45, CD30

End of Lymphoma - B cell neoplasms > B cell lymphoma subtypes > ALK-positive large B-cell lymphoma


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