Lymphoma and plasma cell neoplasms
B cell lymphoma subtypes
ALK-positive large B cell lymphoma

Author: Nikhil Sangle, M.D. (see Authors page)

Revised: 3 April 2017, last major update March 2011

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PubMed Search: ALK-positive large B cell lymphoma

Cite this page: ALK positive large B cell lymphoma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/lymphomaALKpositive.html. Accessed May 24th, 2017.
Definition / general
  • Very rare neoplasm of immunoblast-like ALK-positive B cells that lacks the t(2;5) translocation characteristic of anaplastic large cell lymphoma
Etiology
  • Originates from post germinal center B cells with plasma cell differentiation
Clinical features
  • Male predominance; median age = 36 years
  • Mediastinal and nodal involvement common
  • Poor prognosis; median survival for stage III / IV = 11 months
Microscopic (histologic) description
  • Sinusoidal pattern of lymph node involvement; immunoblastic and plasmablastic cells with abundant cytoplasm and round pale nuclei with prominent nucleoli
Positive stains
Negative stains