Lymphoma & related disorders
Mature B cell neoplasms
Large B cell lymphomas-special subtypes

Topic Completed: 1 March 2011

Minor changes: 5 July 2020

Copyright: 2001-2020,, Inc.

PubMed Search: ALK-positive large B cell lymphoma

Nikhil Sangle, M.D.
Page views in 2019: 1,052
Page views in 2020 to date: 893
Cite this page: Sangle N. ALK+. website. Accessed August 11th, 2020.
Definition / general
  • Very rare neoplasm of immunoblast-like ALK-positive B cells that lacks the t(2;5) translocation characteristic of anaplastic large cell lymphoma
  • Originates from post-germinal center B cells with plasma cell differentiation
Clinical features
  • Male predominance; median age = 36 years
  • Mediastinal and nodal involvement common
  • Poor prognosis; median survival for stage III / IV = 11 months
Microscopic (histologic) description
  • Sinusoidal pattern of lymph node involvement; immunoblastic and plasmablastic cells with abundant cytoplasm and round pale nuclei with prominent nucleoli
Positive stains
Negative stains
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