Home   Chapter Home   Jobs   Conferences   Fellowships   Books


Lymphoma - B cell neoplasms

B cell lymphoma subtypes

ALK-positive large B-cell lymphoma

Reviewer: Nikhil Sangle, M.D., University of Utah and ARUP Laboratories (see Reviewers page)
Revised: 20 March 2011, last major update March 2011
Copyright: (c) 2001-2011, PathologyOutlines.com, Inc.


● Very rare neoplasm of immunoblast-like ALK-positive B-cells that lacks the t(2;5) translocation characteristic of anaplastic large cell lymphoma


● Originates from post-germinal center B cells with plasma cell differentiation

Clinical features

● Male predominance; median age = 36 years
● Mediastinal and nodal involvement common
● Poor prognosis; median survival for stage III/IV = 11 months

Micro images

● Sinusoidal pattern of lymph node involvement; immunoblastic and plasmablastic cells with abundant cytoplasm and round pale nuclei with prominent nucleoli

Positive stains

● ALK, EMA, CD138, IgA/IgG, restricted light chain expression
● Also CD4, CD57 and IRF4/MUM1
● Variable cytokeratin

Negative stains

● CD3, CD20, CD79a, CD45, CD30

End of Lymphoma - B cell neoplasms > B cell lymphoma subtypes > ALK-positive large B-cell lymphoma

This information is intended for physicians and related personnel, who understand that medical information is often imperfect, and must be interpreted in the context of a patient's clinical data using reasonable medical judgment. This website should not be used as a substitute for the advice of a licensed physician.

All information on this website is protected by copyright of PathologyOutlines.com, Inc. Information from third parties may also be protected by copyright. Please contact us at [email protected] with any questions (click here for other contact information).