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Table of Contents
Clinical features | Case reports | Microscopic (histologic) description | Microscopic (histologic) images | Positive stains | Negative stains | Molecular / cytogenetics description | Differential diagnosisCite this page: Sangle N. Mantle cell lymphoma - blastoid variant. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/lymphomaMCLblastoid.html. Accessed March 26th, 2019.
Clinical features
- Median age 63 years, range 40 - 79 years; 80% men
- Moderate to marked leukocytosis
- Aggressive behavior
Case reports
- Leukemic mantle cell lymphoma with classic and blastoid components with different immunophenotypes (Am J Clin Pathol 2004;122:122)
Microscopic (histologic) description
- Diffuse, nodular or mantle zone pattern
- Higher grade histologic features than classic mantle cell
- Either (a) lymphoblastic with intermediate size cells containing round nuclei and finely disbursed chromatin, marked mitotic activity and leukemic involvement, resembling CLL / SLL or AML; or (b) pleomorphic with heterogeneous larger cells with deeply indented, pleomorphic nuclei and variably prominent nucleoli, high proliferation rate, often with striking staining of chromatin due to tetraploid clones, resembling diffuse large B cell lymphoma
Microscopic (histologic) images
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Cases with prominent nucleoli
Molecular / cytogenetics description
- t(11;14)
- Blastoid variant is also associated with c-MYC and 8q24 abnormalities (Mod Pathol 2002;15:1266)
- Usually complex karyotypes with 3+ additional chromosomal abnormalities, most commonly chromosome 13; also 18, 17, 8 and 3 (Hum Pathol 2003;34:1022)
Differential diagnosis
- Transformation of B-PLL: variable CD5+, background of CLL type cells, lower N/C ratio, prominent nucleoli (Am J Clin Path 2002;117:246)
- Transformation of CLL: clinical history, CLL cases resemble ALL-L3, CD23+ (Mod Pathol 1997;10:818)
