Lymphoma and plasma cell neoplasms
Plasma cell neoplasms
Osteosclerotic myeloma (POEMS syndrome)

Author: Nikhil Sangle, M.D. (see Authors page)

Revised: 3 April 2017, last major update March 2011

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PubMed Search: osteosclerotic myeloma (POEMS syndrome)

Cite this page: Osteosclerotic myeloma (POEMS syndrome). PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/lymphomaPOEMS.html. Accessed April 30th, 2017.
Definition / general
  • Plasma cell myeloma characterized by osteosclerotic changes in the bony trabeculae with associated paratrabecular fibrosis
Clinical features
  • Often a component of POEMS syndrome (polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy and skin changes)
  • Usually less than 5% plasma cells
  • Relation to typical plasma cell myeloma is unknown
  • Associated with lymph node changes resembling the plasma cell variant of Castleman disease