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Lymphoma - B cell neoplasms

Plasma cell neoplasms

Osteosclerotic myeloma (POEMS syndrome)


Reviewer: Nikhil Sangle, M.D., University of Utah and ARUP Laboratories (see Reviewers page)
Revised: 13 March 2011, last major update March 2011
Copyright: (c) 2001-2011, PathologyOutlines.com, Inc.

Definition
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● Plasma cell myeloma characterized by osteosclerotic changes in the bony trabeculae with associated paratrabecular fibrosis

Clinical features
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● Often a component of POEMS syndrome (polyneuropathy, organomegaly, endocrinopahty, monoclonal gammopathy and skin changes)
● Usually less than 5% plasma cells
● Relation to typical plasma cell myeloma is unknown
● Associated with lymph node changes resembling the plasma cell variant of Castlemanís disease

End of Lymphoma - B cell neoplasms > Plasma cell neoplasms > Osteosclerotic myeloma (POEMS syndrome)


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