Cite this page: Sangle N. B cell disorders - General. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/lymphomabcellgeneral.html. Accessed May 26th, 2020.
Definition / general
- Almost always surface immunoglobulin light chain restricted
- Loss of surface membrane immunoglobulin by B cells in extramedullary sites usually indicates lymphoma, but rarely is present with hyperplasia (Am J Clin Pathol 2005;124:143)
- Low grade tumors may have extensive sarcoid-like granulomas (Arch Pathol Lab Med 2000;124:152)
- B cell non-Hodgkin lymphomas rarely are CD2+, but behavior is similar to CD2- tumors; must differentiate from composite B, T cell lymphomas (Am J Clin Path 2001;115:396)