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Lymphoma - B cell neoplasms

B cell disorders - general


Reviewer: Nikhil Sangle, M.D., University of Utah and ARUP Laboratories (see Reviewers page)
Revised: 2 February 2011, last major update February 2011
Copyright: (c) 2001-2011, PathologyOutlines.com, Inc.

General
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● Almost always surface immunoglobulin light chain restricted
● Loss of surface membrane immunoglobulin by B cells in extramedullary sites usually indicates lymphoma, but rarely is present with hyperplasia (Am J Clin Pathol 2005;124:143)
● Low grade tumors may have extensive sarcoid-like granulomas (Arch Pathol Lab Med 2000;124:152)
● B cell non-Hodgkin lymphomas rarely are CD2+, but behavior is similar to CD2- tumors; must differentiate from composite B, T cell lymphomas (Am J Clin Path 2001;115:396)

Micro images
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Granulomas in low grade lymphoma

End of Lymphoma - B cell neoplasms > B cell disorders - general


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