Lymphoma and plasma cell neoplasms
B cell disorders

Topic Completed: 1 February 2011

Minor changes: 16 March 2020

Copyright: 2001-2020,, Inc.

PubMed Search: b cell lymphoma disorder

Nikhil Sangle, M.D.
Page views in 2019: 361
Page views in 2020 to date: 197
Cite this page: Sangle N. B cell disorders - General. website. Accessed May 26th, 2020.
Definition / general
  • Almost always surface immunoglobulin light chain restricted
  • Loss of surface membrane immunoglobulin by B cells in extramedullary sites usually indicates lymphoma, but rarely is present with hyperplasia (Am J Clin Pathol 2005;124:143)
  • Low grade tumors may have extensive sarcoid-like granulomas (Arch Pathol Lab Med 2000;124:152)
  • B cell non-Hodgkin lymphomas rarely are CD2+, but behavior is similar to CD2- tumors; must differentiate from composite B, T cell lymphomas (Am J Clin Path 2001;115:396)
Microscopic (histologic) images

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Granulomas in low grade lymphoma

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