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Lymphoma - B cell neoplasms

B cell disorders

WHO classification of B cell lymphoid neoplasms


Reviewer: Nikhil Sangle, M.D., University of Utah and ARUP Laboratories (see Reviewers page)
Revised: 12 February 2011, last major update February 2011
Copyright: (c) 2001-2011, PathologyOutlines.com, Inc.

Classification
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Precursor B cell neoplasms:
● Precursor B lymphoblastic leukemia/lymphoma

Mature (peripheral) B cell neoplasms:
● Chronic lymphocytic leukemia/small lymphocytic lymphoma
● B cell prolymphocytic leukemia
● Splenic marginal zone lymphoma
● Hairy cell leukemia
Splenic lymphoma/leukemia, unclassifiable
      Splenic diffuse red pulp small B-cell lymphoma*
      Hairy cell leukemia-variant*
● Lymphoplasmacytic lymphoma
      Waldenstrom macroglobulinemia
● Heavy chain diseases (alpha, gamma, mu)
● Plasma cell myeloma
● Solitary plasmacytoma of bone
● Extraosseous plasmacytoma
● Extranodal marginal zone B-cell lymphoma of muocsa associated lymphoid tissue (MALT lymphoma)
● Nodal marginal zone B-cell lymphoma (MZL)
      Pediatric type nodal MZL
● Follicular lymphoma
      Pediatric type follicular lymphoma
● Primary cutaneous follicle center lymphoma
● Mantle cell lymphoma
● Diffuse large B cell lymphoma (DLBCL), not otherwise specified
      T cell/histiocyte rich large B-cell lymphoma
      DLBCL associated with chronic inflammation
      Epstein-Barr virus (EBV)+ DLBCL of the elderly
● Lymphomatoid granulomatosis
● Primary mediastinal (thymic) large B cell lymphoma
● Intravascular large B cell lymphoma
Primary cutaneous DLBCL, leg type
● ALK+ large B-cell lymphoma
● Plasmablastic lymphoma
● Primary effusion lymphoma
Large B-cell lymphoma arising in HHV8-associated multicentric Castleman disease
● Burkitt lymphoma
B-cell lymphoma, unclassifiable, with features intermediate between diffuse large B-cell lymphoma and Burkitt lymphoma
● B-cell lymphoma, unclassifiable, with features intermediate between diffuse large B-cell lymphoma and classical Hodgkin lymphoma

Hodgkin Lymphoma
● Nodular lymphocyte-predominant Hodgkin lymphoma
● Classical Hodgkin lymphoma
      Nodular sclerosis classical Hodgkin lymphoma
      Lymphocyte-rich classical Hodgkin lymphoma
      Mixed cellularity classical Hodgkin lymphoma
      Lymphocyte-depleted classical Hodgkin lymphoma

● Diseases in italics are new to the 2008 WHO classification
● An asterisk (*) refers to provisional entities or provisional subtypes of other neoplasms

Table, SEER table, Table comparing 2010 to 2008 #1, #2

References: Hematology Am Soc Hematol Educ Program 2009:523, J Hematop 2009 Jun 25 [Epub ahead of print]

End of Lymphoma - B cell neoplasms > WHO classification


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