Lymphoma and plasma cell neoplasms
B cell disorders
WHO classification of B cell lymphoid neoplasms

Author: Nikhil Sangle, M.D. (see Authors page)

Revised: 3 April 2017, last major update February 2011

Copyright: (c) 2001-2017, PathologyOutlines.com, Inc.

PubMed Search: WHO classification of B cell lymphoid neoplasms

Cite this page: WHO classification of B cell lymphoid neoplasms. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/lymphomabcellwho.html. Accessed August 21st, 2017.
Diagrams / tables

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WHO 2008: the mature B cell neoplasms

SEER table

WHO histological classification of mature B cell neoplasms

Classification of aggressive B cell lymphomas

Classification
Precursor B cell neoplasms:
  • Precursor B lymphoblastic leukemia / lymphoma

Mature (peripheral) B cell neoplasms:
  • Chronic lymphocytic leukemia / small lymphocytic lymphoma
  • B cell prolymphocytic leukemia
  • Splenic marginal zone lymphoma
  • Hairy cell leukemia
  • Splenic lymphoma / leukemia, unclassifiable
    • Splenic diffuse red pulp small B cell lymphoma*
    • Hairy cell leukemia variant*
  • Lymphoplasmacytic lymphoma
    • Waldenstrom macroglobulinemia
  • Heavy chain diseases (alpha, gamma, mu)
  • Plasma cell myeloma
  • Solitary plasmacytoma of bone
  • Extraosseous plasmacytoma
  • Extranodal marginal zone B cell lymphoma of muocsa associated lymphoid tissue (MALT lymphoma)
  • Nodal marginal zone B cell lymphoma (MZL)
    • Pediatric type nodal MZL
  • Follicular lymphoma
    • Pediatric type follicular lymphoma
  • Primary cutaneous follicle center lymphoma
  • Mantle cell lymphoma
  • Diffuse large B cell lymphoma (DLBCL), not otherwise specified
    • T cell / histiocyte rich large B cell lymphoma
    • DLBCL associated with chronic inflammation
    • Epstein-Barr virus (EBV)+ DLBCL of the elderly
  • Lymphomatoid granulomatosis
  • Primary mediastinal (thymic) large B cell lymphoma
  • Intravascular large B cell lymphoma
  • Primary cutaneous DLBCL, leg type
  • ALK+ large B cell lymphoma
  • Plasmablastic lymphoma
  • Primary effusion lymphoma
  • Large B cell lymphoma arising in HHV8 associated multicentric Castleman disease
  • Burkitt lymphoma
  • B cell lymphoma, unclassifiable, with features intermediate between diffuse large B cell lymphoma and Burkitt lymphoma
  • B cell lymphoma, unclassifiable, with features intermediate between diffuse large B cell lymphoma and classical Hodgkin lymphoma

Hodgkin Lymphoma:
  • Nodular lymphocyte predominant Hodgkin lymphoma
  • Classical Hodgkin lymphoma
    • Nodular sclerosis classical Hodgkin lymphoma
    • Lymphocyte rich classical Hodgkin lymphoma
    • Mixed cellularity classical Hodgkin lymphoma
    • Lymphocyte depleted classical Hodgkin lymphoma

Note:
  • Diseases in italics are new to the 2008 WHO classification
  • An asterisk (*) refers to provisional entities or provisional subtypes of other neoplasms