Lymphoma - B cell neoplasms
Non-Hodgkin lymphoma
Chemotherapeutic atypia

Author: Nikhil Sangle, M.D. (see Authors page)

Revised: 1 March 2017, last major update February 2011

Copyright: (c) 2001-2017,, Inc.

PubMed Search: chemotherapeutic atypia

Cite this page: Chemotherapeutic atypia. website. Accessed March 29th, 2017.
Definition / General
  • Chemotherapeutic agents, particularly alkylating agents, can induce bizarre epithelial atypia
  • Observed in lower respiratory tract and sinonasal tract
  • Includes patients treated for leukemia and myeloma
Micro Description
  • Striking nuclear enlargement, hyperchromasia and pleomorphism
  • Changes may be full thickness, and be associated with squamous metaplasia
Differential Diagnosis