Lymphoma and plasma cell neoplasms
Non-Hodgkin lymphoma
Chemotherapeutic atypia



Topic Completed: 1 February 2011

Revised: 6 February 2019

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PubMed Search: chemotherapeutic atypia


Nikhil Sangle, M.D.
Page views in 2018: 51
Page views in 2019 to date: 34
Cite this page: Sangle N. Chemotherapeutic atypia. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/lymphomachemo.html. Accessed September 16th, 2019.
Definition / general
  • Chemotherapeutic agents, particularly alkylating agents, can induce bizarre epithelial atypia
  • Observed in lower respiratory tract and sinonasal tract
  • Includes patients treated for leukemia and myeloma
Microscopic (histologic) description
  • Striking nuclear enlargement, hyperchromasia and pleomorphism
  • Changes may be full thickness, and be associated with squamous metaplasia
Differential diagnosis
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