Lymphoma and plasma cell neoplasms
Non-Hodgkin lymphoma
Chemotherapeutic atypia

Author: Nikhil Sangle, M.D. (see Authors page)

Revised: 3 March 2017, last major update February 2011

Copyright: (c) 2001-2017,, Inc.

PubMed Search: chemotherapeutic atypia

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Cite this page: Chemotherapeutic atypia. website. Accessed January 23rd, 2019.
Definition / general
  • Chemotherapeutic agents, particularly alkylating agents, can induce bizarre epithelial atypia
  • Observed in lower respiratory tract and sinonasal tract
  • Includes patients treated for leukemia and myeloma
Microscopic (histologic) description
  • Striking nuclear enlargement, hyperchromasia and pleomorphism
  • Changes may be full thickness, and be associated with squamous metaplasia
Differential diagnosis