Lymphoma and plasma cell neoplasms
Plasma cell neoplasms

Topic Completed: 1 March 2011

Revised: 21 May 2019

Copyright: (c) 2001-2017,, Inc.

PubMed Search: cryoglobulinemia lymphoma

Nikhil Sangle, M.D.
Page views in 2018: 183
Page views in 2019 to date: 93
Cite this page: Sangle N. Cryoglobulinemia. website. Accessed September 16th, 2019.
Definition / general
  • Proteins that precipitate as serum is cooled but before 37°C, redissolve upon warming
  • Either simple / type I (monoclonal), mixed / type II (two types of monoclonal immunoglobulin, usually IgG and IgM) or mixed / type III (like type II but polyclonal)
  • Type I: associated with multiple myeloma, lymphoplasmacytic lymphoma
  • Type II: associated with chronic active hepatitis C infection, autoimmune disease, non-Hodgkin lymphoma, lymphoplasmacytic lymphoma
  • Type III: associated with chronic infection and autoimmune disease
Clinical features
  • Often no symptoms; also Raynaud phenomenon, ulceration, purpura
  • Corticosteroids, plasmapheresis
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