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Lymphoma - B cell neoplasms

Plasma cell neoplasms

Cryoglobulinemia

Reviewer: Nikhil Sangle, M.D., University of Utah and ARUP Laboratories (see Reviewers page)
Revised: 13 March 2011, last major update March 2011
Copyright: (c) 2001-2011, PathologyOutlines.com, Inc.

Definition of cryoglobulins
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● Proteins that precipitate as serum is cooled but before 37C, redissolve upon warming
● Either simple/ type I (monoclonal), mixed / type II (two types of monoclonal immunoglobulin, usually IgG and IgM) or mixed / type III (like type II but polyclonal)
● Type I: associated with multiple myeloma, lymphoplasmacytic lymphoma
● Type II: associated with chronic active hepatitis C infection, autoimmune disease, non-Hodgkin lymphoma, lymphoplasmacytic lymphoma
● Type III: associated with chronic infection and autoimmune disease

Clinical features
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● Often no symptoms; also Raynaud’s phenomenon, ulceration, purpura

Treatment
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● Corticosteroids, plasmapheresis

End of Lymphoma - B cell neoplasms > Plasma cell neoplasms > Cryoglobulinemia

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