Lymphoma - B cell neoplasms - CD5+ diffuse large B cell lymphoma

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Lymphoma - B cell neoplasms

B cell lymphoma subtypes

Diffuse large B cell lymphoma - CD5+

Reviewer: Nikhil Sangle, M.D., University of Utah and ARUP Laboratories (see Reviewers page)
Revised: 2 January 2011, last major update January 2011
Copyright: (c) 2001-2011, PathologyOutlines.com, Inc.

Epidemiology
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● 5-10% of diffuse large B cell lymphomas

Clinical features
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● Heterogeneous, but some may have diffuse splenic red pulp involvement
● Poorer prognosis than CD5 negative diffuse large B cell lymphoma (Ann Oncol 2010;21:2069)
● Most cases do not appear to be related to CLL/SLL or mantle cell lymphoma (Am J Clin Pathol 2000;114:523)
● CNS recurrence in 13% (Haematologica 2008;93:1195)

Micro images
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Morphologic variants

CD5+, bcl2+, CD20+

Arising from follicular lymphoma

Positive stains
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● CD19, CD20, CD5, bcl2, often FMC7

Negative stains
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● Cyclin D1; usually CD10, CD23 (Blood 2002;99:815)

Differential diagnosis
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● Mantle cell lymphoma (usually intermediate grade cells, not high grade; cyclin D1+)
● SLL/CLL (low grade morphology)

End of Lymphoma - B cell neoplasms > B cell lymphoma subtypes > Diffuse large B cell lymphoma - CD5+

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