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Lymphoma - B cell neoplasms

B cell lymphoma subtypes

Pyothorax associated lymphoma

Reviewer: Nikhil Sangle, M.D., University of Utah and ARUP Laboratories (see Reviewers page)
Revised: 20 March 2011, last major update March 2011
Copyright: (c) 2001-2011, PathologyOutlines.com, Inc.


● Rare tumor associated with history of chronic pyothorax or chronic pleuritis due to therapeutic artificial pneumothorax for pleuropulmonary tuberculosis (used in the past as surgical treatment for tuberculosis, (Am J Surg Pathol 2002;26:724)

Clinical features

● Associated with chronic pyothorax or chronic pleuritis; duration between onset of chronic inflammation and lymphoma is about 10 years
● Presents with pleural mass, occasionally liver involvement
● Tumor cells derive from late germinal center or post-germinal center cells (negative for CD10 and bcl6, positive for MUM1 and CD138)
● Morphologic features are similar to diffuse large B cell lymphoma, but patterns of gene expression by microarray are different (Cancer Sci 2004;95:828)
● Median survival is 5 months

Micro description

● Diffuse proliferation of large lymphoid cells with frequent plasmacytoid differentiation

Positive stains

● Occasionally CD138, CD2, CD3, CD4

Negative stains

● HHV-8, CD10, bcl6


● Immunoglobulin light chain restriction, clonal B cell population, EBV genome

End of Lymphoma - B cell neoplasms > B cell lymphoma subtypes > Pyothorax associated lymphoma

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