Lymphoma and plasma cell neoplasms
B cell lymphoma subtypes
Pyothorax associated lymphoma

Author: Nikhil Sangle, M.D. (see Authors page)

Revised: 3 April 2017, last major update March 2011

Copyright: (c) 2001-2017,, Inc.

PubMed Search: pyothorax associated lymphoma

Cite this page: Pyothorax associated lymphoma. website. Accessed April 23rd, 2017.
Definition / General
  • Rare tumor associated with history of chronic pyothorax or chronic pleuritis due to therapeutic artificial pneumothorax for pleuropulmonary tuberculosis (used in the past as surgical treatment for tuberculosis, Am J Surg Pathol 2002;26:724)
Clinical Features
  • Associated with chronic pyothorax or chronic pleuritis; duration between onset of chronic inflammation and lymphoma is about 10 years
  • Presents with pleural mass, occasionally liver involvement
  • Tumor cells derive from late germinal center or postgerminal center cells (negative for CD10 and BCL6, positive for MUM1 and CD138)
  • Morphologic features are similar to diffuse large B cell lymphoma, but patterns of gene expression by microarray are different (Cancer Sci 2004;95:828)
  • Median survival is 5 months
Micro Description
  • Diffuse proliferation of large lymphoid cells with frequent plasmacytoid differentiation
Positive Stains
Negative Stains
Molecular / Cytogenetics Description
  • Immunoglobulin light chain restriction, clonal B cell population, EBV genome