Lymphoma and plasma cell neoplasms
B cell lymphoma subtypes
Pyothorax associated lymphoma



Topic Completed: 1 March 2011

Minor changes: 16 March 2020

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PubMed Search: pyothorax associated lymphoma


Nikhil Sangle, M.D.
Page views in 2019: 164
Page views in 2020 to date: 97
Cite this page: Sangle N. Pyothorax associated lymphoma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/lymphomadiffusepyo.html. Accessed June 7th, 2020.
Definition / general
  • Rare tumor associated with history of chronic pyothorax or chronic pleuritis due to therapeutic artificial pneumothorax for pleuropulmonary tuberculosis (used in the past as surgical treatment for tuberculosis, Am J Surg Pathol 2002;26:724)
Clinical features
  • Associated with chronic pyothorax or chronic pleuritis; duration between onset of chronic inflammation and lymphoma is about 10 years
  • Presents with pleural mass, occasionally liver involvement
  • Tumor cells derive from late germinal center or postgerminal center cells (negative for CD10 and BCL6, positive for MUM1 and CD138)
  • Morphologic features are similar to diffuse large B cell lymphoma, but patterns of gene expression by microarray are different (Cancer Sci 2004;95:828)
  • Median survival is 5 months
Microscopic (histologic) description
  • Diffuse proliferation of large lymphoid cells with frequent plasmacytoid differentiation
Positive stains
Negative stains
Molecular / cytogenetics description
  • Immunoglobulin light chain restriction, clonal B cell population, EBV genome
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