Lymphoma - B cell neoplasms
B cell lymphoma subtypes
Pyothorax associated lymphoma
Reviewer: Nikhil Sangle, M.D., University of Utah and ARUP Laboratories (see Reviewers page)
Revised: 20 March 2011, last major update March 2011
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● Rare tumor associated with history of chronic pyothorax or chronic pleuritis due to therapeutic artificial pneumothorax for pleuropulmonary tuberculosis (used in the past as surgical treatment for tuberculosis, (Am J Surg Pathol 2002;26:724)
● Associated with chronic pyothorax or chronic pleuritis; duration between onset of chronic inflammation and lymphoma is about 10 years
● Presents with pleural mass, occasionally liver involvement
● Tumor cells derive from late germinal center or post-germinal center cells (negative for CD10 and bcl6, positive for MUM1 and CD138)
● Morphologic features are similar to diffuse large B cell lymphoma, but patterns of gene expression by microarray are different (Cancer Sci 2004;95:828)
● Median survival is 5 months
● Diffuse proliferation of large lymphoid cells with frequent plasmacytoid differentiation
● CD20, CD79a, EBV LMP, EBV EBNA, IRF4/MUM1
● Occasionally CD138, CD2, CD3, CD4
● HHV-8, CD10, bcl6
● Immunoglobulin light chain restriction, clonal B cell population, EBV genome
End of Lymphoma - B cell neoplasms > B cell lymphoma subtypes > Pyothorax associated lymphoma
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