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Lymphoma - B cell neoplasms

Follicular lymphoma-childhood tumors


Reviewer: Nikhil Sangle, M.D., University of Utah and ARUP Laboratories (see Reviewers page)
Revised: 6 January 2011, last major update January 2011
Copyright: (c) 2001-2011, PathologyOutlines.com, Inc.

Clinical features
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● Rare in children
● Commonly presents as localized disease of head and neck, lymph nodes or tonsils
● Simultaneous diffuse large B-cell lymphoma is frequently presesnt at initial diagnosis, but does not indicate an aggressive clinical course
● Good response to therapy with complete remission, excellent prognosis and few relapses
● Testicular tumors are very rare, have good prognosis (Cancer 1999;85:1626)

Micro images
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● High grade cytology (grade 3, Blood 2002;99:1959)
● Characteristic features include total or extensive replacement of nodal structure, even distribution of nodules throughout the lesion, crowding of nodules with little interposed lymphoid tissue, uniformity in size and shape of nodules, lack of immunoblasts and plasma cells in interfollicular areas, atypical cells within nodules (Arch Pathol Lab Med 2009;133:142)

Micro images
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Various images

Testicular tumor

Positive stains
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● Variable bcl2 expression

Molecular
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● Negative t(14;18) (Haematologica 2010;95:253)

Differential diagnosis
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Follicular hyperplasia: no effacement of nodal architecture, no atypical cells; cortical (not even) distribution of follicles; nodules are not uniform (Arch Pathol Lab Med 2009;133:142)

End of Lymphoma - B cell neoplasms > Follicular lymphoma-childhood tumors


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