Lymphoma and plasma cell neoplasms
Follicular lymphoma
Childhood tumors

Topic Completed: 1 January 2011

Revised: 13 March 2020

Copyright: (c) 2001-2020,, Inc.

PubMed Search: childhood follicular lymphoma

Nikhil Sangle, M.D.
Page views in 2019: 685
Page views in 2020 to date: 198
Cite this page: Sangle N. Childhood tumors. website. Accessed April 1st, 2020.
Clinical features
  • Rare in children
  • Commonly presents as localized disease of head and neck, lymph nodes or tonsils
  • Simultaneous diffuse large B cell lymphoma is frequently present at initial diagnosis, but does not indicate an aggressive clinical course
  • Good response to therapy with complete remission, excellent prognosis and few relapses
  • Testicular tumors are very rare, have good prognosis (Cancer 1999;85:1626)
Microscopic (histologic) description
  • High grade cytology (grade 3, Blood 2002;99:1959)
  • Characteristic features include total or extensive replacement of nodal structure, even distribution of nodules throughout the lesion, crowding of nodules with little interposed lymphoid tissue, uniformity in size and shape of nodules, lack of immunoblasts and plasma cells in interfollicular areas, atypical cells within nodules (Arch Pathol Lab Med 2009;133:142)
Microscopic (histologic) images

Images hosted on other servers:

Various images

Testicular tumor

Positive stains
  • Variable BCL2 expression
Molecular / cytogenetics description
Differential diagnosis
  • Follicular hyperplasia: no effacement of nodal architecture, no atypical cells; cortical (not even) distribution of follicles; nodules are not uniform (Arch Pathol Lab Med 2009;133:142)
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