Lymphoma - B cell neoplasms
Follicular lymphoma-childhood tumors
Reviewer: Nikhil Sangle, M.D., University of Utah and ARUP Laboratories (see Reviewers page)
Revised: 6 January 2011, last major update January 2011
Copyright: (c) 2001-2011, PathologyOutlines.com, Inc.
● Rare in children
● Commonly presents as localized disease of head and neck, lymph nodes or tonsils
● Simultaneous diffuse large B-cell lymphoma is frequently presesnt at initial diagnosis, but does not indicate an aggressive clinical course
● Good response to therapy with complete remission, excellent prognosis and few relapses
● Testicular tumors are very rare, have good prognosis (Cancer 1999;85:1626)
● High grade cytology (grade 3, Blood 2002;99:1959)
● Characteristic features include total or extensive replacement of nodal structure, even distribution of nodules throughout the lesion, crowding of nodules with little interposed lymphoid tissue, uniformity in size and shape of nodules, lack of immunoblasts and plasma cells in interfollicular areas, atypical cells within nodules (Arch Pathol Lab Med 2009;133:142)
● Variable bcl2 expression
● Negative t(14;18) (Haematologica 2010;95:253)
● Follicular hyperplasia: no effacement of nodal architecture, no atypical cells; cortical (not even) distribution of follicles; nodules are not uniform (Arch Pathol Lab Med 2009;133:142)
End of Lymphoma - B cell neoplasms > Follicular lymphoma-childhood tumors
This information is intended for physicians and related personnel, who understand that medical information is often imperfect, and must be interpreted in the context of a patient's clinical data using reasonable medical judgment. This website should not be used as a substitute for the advice of a licensed physician.
All information on this website is protected by copyright of PathologyOutlines.com, Inc. Information from third parties may also be protected by copyright. Please contact us at copyrightPathOut@gmail.com with any questions (click here for other contact information).