Lymphoma and plasma cell neoplasms
Follicular lymphoma

Author: Nikhil Sangle, M.D. (see Authors page)

Revised: 25 July 2018, last major update January 2011

Copyright: (c) 2001-2018,, Inc.

PubMed Search: follicular lymphoma gastrointestinal

Cite this page: Sangle, N. Gastrointestinal. website. Accessed October 23rd, 2018.
Definition / general
  • Uncommon
  • For primary disease, median age is 54 years
  • May be slight female predominance
  • Origin of duodenal tumors appears distinct from nodal follicular lymphomas, but more similar to MALT lymphoma (Mod Pathol 2009;22:940)
Clinical features
  • Treatment somewhat controversial since disease is rare and usually presents as low stage, but often multifocal (World J Gastroenterol 2010;16:5543)
  • Rituximab with chemotherapy (cyclophosphamide, vincristine and prednisone, possibly doxorubicin)
  • Also surgery, watchful waiting
  • Possibly antibiotics (Ann Oncol 2008;19:254)
  • Follow up with endoscopy (standard, capsule or double balloon)
Clinical images

Images hosted on other servers:

Endoscopic images

Gross description
  • Bowel wall thickening with multiple elevated nodules or plaques, possible bowel obstruction
Microscopic (histologic) description
  • Associated with lymphomatous polyposis
  • Usually low grade and low stage; often transmural involvement
  • Composed of neoplastic follicles with small cleaved cells
  • Predominantly follicular growth pattern, occasionally mixed with diffuse, rarely entirely diffuse
Microscopic (histologic) images

Images hosted on other servers:

Various images

Positive stains
Negative stains
Molecular / cytogenetics description
  • t(14;18) - the standard translocation for follicular lymphoma; associated with poorer clinical course