Lymphoma - B cell neoplasms - Hemophagocytic syndrome

Home Chapter Home Jobs Conferences Fellowships Books

Lymphoma - B cell neoplasms

Non-Hodgkin Lymphoma

Hemophagocytic syndrome

Reviewer: Nikhil Sangle, M.D., University of Utah and ARUP Laboratories (see Reviewers page)
Revised: 17 February 2011, last major update February 2011
Copyright: (c) 2001-2011, PathologyOutlines.com, Inc.

Definition
=========================================================================

● May be associated with non-Hodgkin lymphoma (most common: diffuse large B cell, T cell, NK)
● Systemic presentation (fever, splenomegaly, jaundice), survival < 2 years, mild interstitial lymphoid infiltrate of bone marrow at presentation (Am J Surg Pathol 2001;25:865)

Treatment
=========================================================================

● Cytotoxic chemotherapy if EBV related vs. treatment of infection in non-EBV infection

Gross
=========================================================================

● Often no pronounced tumor mass

Micro
=========================================================================

● Hemophagocytosis (phagocytosis by macrophages of white blood cells, red blood cells, platelets and precursors)
● In bone marrow, mild interstitial lymphoid infiltrate at presentation

Positive stains
=========================================================================

● Depends on tumor type

Molecular
=========================================================================

● Occasional HHV6 positivity by PCR

End of Lymphoma - B cell neoplasms > Non-Hodgkin Lymphoma > Hemophagocytic syndrome

This information is intended for physicians and related personnel, who understand that medical information is often imperfect, and must be interpreted in the context of a patient's clinical data using reasonable medical judgment. This website should not be used as a substitute for the advice of a licensed physician.

All information on this website is protected by copyright of PathologyOutlines.com, Inc. Information from third parties may also be protected by copyright. Please contact us at copyrightPathOut@gmail.com with any questions (click here for other contact information).