Lymphoma & related disorders
Posttransplantation lymphoproliferative disorders (PTLD)
Infectious mononucleosis PTLD



Topic Completed: 1 August 2011

Minor changes: 1 April 2020

Copyright: 2002-2020, PathologyOutlines.com, Inc.

PubMed Search: Infectious mononucleosis PTLD


Dragos C. Luca, M.D.
Page views in 2020 to date: 31
Cite this page: Luca D. Infectious mononucleosis PTLD. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/lymphomainfectiousmonoptld.html. Accessed May 26th, 2020.
Definition / general
  • Lymphoid proliferations in an allograft recipient, characterized by architectural preservation of the involved tissue, with preservation of the nodal sinuses or tonsillar crypts, and residual and sometimes floridly reactive follicles, usually forming mass lesions (WHO Classification, 2008)
  • Must exclude other lymphoid proliferations or nonspecific inflammatory processes
Clinical features
  • Younger age than other PTLD, often in solid organs with no prior EBV infection
  • Involves lymph nodes and tonsils / adenoids more often than extranodal sites
  • Frequent spontaneous regression or regression after reduction of immunosuppression
  • Poly or mono PTLD may follow; IM-like cases may be fatal
Microscopic (histologic) description
  • Plasmacytic hyperplasia: numerous plasma cells, small lymphocytes, occasional immunoblasts
  • IM-like: paracortical expansion, numerous immunoblasts, background of T cells and plasma cells, normal architecture may be partially destroyed
  • Florid follicular hyperplasia may also occur; criteria not well defined to distinguish from reactive follicular hyperplasia
Microscopic (histologic) images

Images hosted on other servers:

Plasmacytic hyperplasia (1A&B)

EBER-ISH (4A)

IM-like PTLD (Multiple images, H&E and IHC)

Immunohistochemistry
  • Polyclonal B cells, plasma cells and T cells with no aberrant biomarkers
  • EBV positive (EBV LMP1): most plasmcytic hyperplasia and florid follicular hyperplasia cases, and virtually all IM-like cases
Molecular / cytogenetics description
  • No clonal rearrangements of the Ig genes
  • Small mono or oligoclonal populations may be detected in IM-like lesions
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