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Lymphoma - B cell neoplasms

B cell lymphoma subtypes

Marginal zone B cell lymphoma - general


Reviewer: Nikhil Sangle, M.D., University of Utah and ARUP Laboratories (see Reviewers page)
Revised: 3 March 2011, last major update March 2011
Copyright: (c) 2001-2011, PathologyOutlines.com, Inc.

Definition
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● Three types of lymphomas with overlapping characteristics: MALT lymphoma, nodal marginal zone lymphoma and splenic marginal zone lymphoma
● All feature a perifollicular proliferation of centrocyte or monocyte-like, irregular small B cells, mixed with larger centroblast or immunoblast-like cells; may have plasmacytoid features

Etiology
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● Marginal zone lymphomas are thought to derive from cells in the nodal or splenic marginal zone, perhaps from B memory cells that are post-germinal center and IgM+, IgD-, based on a low sequence homology between their IgH variable genes and germline genes

Clinical features
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● All usually have bone marrow involvement (Am J Clin Path 2002;117:698)
● Extranodal marginal zone lymphomas in children and young adults are similar to MALT lymphoma in older patients (Am J Surg Pathol 2003;27:522)

Micro description
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● Perifollicular proliferation of centrocyte or monocyte-like, irregular small B cells, mixed with larger centroblast or immunoblast-like cells; may have plasmacytoid features
● The clonal B-cells infiltrate the marginal zone of reactive follicles, and extend into the interfollicular region
● In epithelial-lined tissues, the clonal B-cells infiltrate the epithelial cells to form lymphoepithelial lesions
● Cells resemble monocytoid B cells in lymph node sinuses in toxoplasmosis, cat-scratch disease, AIDS, infectious mononucleosis, autoimmune disorders and other reactive disorders

Stains
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● Plasmacytoid cells may be negative for B cell markers but are strongly immunoreactive for kappa or lambda, and carry a serum paraprotein (M-component) in peripheral blood

End of Lymphoma - B cell neoplasms > B cell lymphoma subtypes > Marginal zone B cell lymphoma - general


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