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Lymphoma - non B cell
Hodgkin lymphoma
Nodular lymphocyte predominant

Reviewer: Lauren B. Smith, M.D. (see Reviewers page)
Revised: 28 April 2014, last major update July 2010
Copyright: (c) 2002-2013, PathologyOutlines.com, Inc.

General
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Epidemiology
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Sites
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Etiology
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Clinical features
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Prognostic factors
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Case reports
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Treatment
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Micro description
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Micro images
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Axillary lymph node


LP cells

3 LP cells with highly irregular nuclear;
contours in a background of small lymphocytes


Large numbers of LP cells

LP cells resemble
RS cell

Wreath of epithelioid histiocytes
surrounds the nodule


Background has small lymphocytes
and epithelioid histiocytes

Nodules are larger than
in follicular lymphoma


Diffuse scattering of LP cells
with vague nodular pattern

Various immunostains

Low power


RS vs. LP cells

Nodular pattern and LP cells


Various images

Only rare Hodgkin cells are identified;
most of infiltrate is small round lymphocytes


T cell/histiocyte rich nodules

Transition to diffuse large cell lymphoma,
with sheets of LP cells in internodular areas


Nodular LP HL and large cell lymphoma

Nodular LP HL and classic interfollicular HL


Submandibular mass


CD20+


CD45RB+; #2-CD45/LCA

CD57+ cells form a wreath around the LP cells


CD3 (low and high power)

CD21

CD30



Contributed by Dr. Lauren B. Smith, University of Michigan (USA):

Low power

LP cell

CD20


Positive stains
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Negative stains
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Molecular description
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Negative staining
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End of Lymphoma - non B cell > Hodgkin lymphoma > Nodular lymphocyte predominant


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